iPTMnet Report for Q15349 (RPS6KA2)
Protein Information
UniProt AC / UniProt ID | Q15349 / KS6A2_HUMAN |
Protein Name | Ribosomal protein S6 kinase alpha-2 |
Gene Name | Name: RPS6KA2 Synonyms:MAPKAPK1C,RSK3; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q15349 |
PRO Name | ribosomal protein S6 kinase alpha-2 (human) |
Definition | A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human. |
Short Label | hRPS6KA2 |
Category | organism-gene |
Q15349 (RPS6KA2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
S27 | Phosphorylation | score1 | PhosphoSitePlus | |||
S28 | Phosphorylation | score1 | PhosphoSitePlus | |||
S30 | Phosphorylation | score1 | PhosphoSitePlus | |||
K91 | Acetylation | score1 | PhosphoSitePlus | |||
K94 | Acetylation | score1 | PhosphoSitePlus | |||
S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y135 | Phosphorylation | score1 | PhosphoSitePlus | |||
K186 | Ubiquitination | score1 | PhosphoSitePlus | |||
S206 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y217 | Phosphorylation | score1 | PhosphoSitePlus | |||
S218 | Phosphorylation | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus UniProt | 10480933, 7642538, 17192257 | ||
S218 | Phosphorylation | O15530 (PDPK1) | score2 | neXtProt | 10480933 | |
S218 | Phosphorylation | Q15349 (RPS6KA2) | score2 | PhosphoSitePlus | 7642538 | |
T222 | Phosphorylation | score1 | PhosphoSitePlus | |||
K295 | Acetylation | score1 | PhosphoSitePlus | |||
T356 | Phosphorylation | score1 | PRO | |||
S360 | Phosphorylation | score1 | PRO | |||
S377 | Phosphorylation | score2 | PRO PhosphoSitePlus UniProt | 19369195 | ||
S381 | Phosphorylation | score1 | PhosphoSitePlus | |||
S388 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y426 | Phosphorylation | score1 | PhosphoSitePlus | |||
K430 | Ubiquitination | score1 | PhosphoSitePlus | |||
K450 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y463 | Phosphorylation | score1 | PhosphoSitePlus | |||
T471 | Phosphorylation | score1 | PhosphoSitePlus | |||
K473 | Ubiquitination | score1 | PhosphoSitePlus | |||
S546 | Phosphorylation | score1 | PhosphoSitePlus | |||
T570 | Phosphorylation | score3 | PRO PhosphoSitePlus | 7642538 | ||
T570 | Phosphorylation | Q15349 (RPS6KA2) | score2 | PhosphoSitePlus | 7642538 | |
Y573 | Phosphorylation | score1 | PhosphoSitePlus | |||
T574 | Phosphorylation | score1 | PhosphoSitePlus | |||
T618 | Phosphorylation | score1 | PhosphoSitePlus | |||
S628 | Phosphorylation | score1 | PhosphoSitePlus | |||
K630 | Ubiquitination | score1 | PhosphoSitePlus | |||
S650 | Phosphorylation | score1 | PhosphoSitePlus | |||
T662 | Phosphorylation | score1 | PhosphoSitePlus | |||
S730 | Phosphorylation | score1 | PRO |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S106 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y217 | Phosphorylation | score0 | HPRD | 18691976 | ||
S218 | Phosphorylation | score0 | HPRD | 17192257 | ||
S218 | Phosphorylation | Q15349 (RPS6KA2) | score0 | HPRD | 17192257 | |
T222 | Phosphorylation | score0 | HPRD | 17192257 | ||
T222 | Phosphorylation | Q15349 (RPS6KA2) | score0 | HPRD | 17192257 | |
S377 | Phosphorylation | score0 | HPRD | 15345747 | ||
T570 | Phosphorylation | score0 | HPRD | 18691976 |
Q15349 (RPS6KA2) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
P16220-1 (CREB1) | S133 | score2 | HPRD | 11175347, 11698596, 8688081, ... | |
P17676 (CEBPB) | S321 | score2 | neXtProt | 20351173 | |
P25963 (NFKBIA) | S32 | score1 | Signor | 20385620 | |
P32004-2 (L1CAM) | S1152 | score1 | HPRD | 8663493 | |
Q15349-1 (RPS6KA2) | S218 | score4 | HPRD PhosphoSitePlus | 7642538, 17192257 | |
Q15349-1 (RPS6KA2) | T222 | score0 | HPRD | 17192257 | |
Q15349 (RPS6KA2) | T570 | score2 | PhosphoSitePlus | 7642538 | |
Q92934 (BAD) | S75 | score3 | HPRD Signor | 12897128, 10880354, 10521512, ... | |
Q92934 (BAD) | S118 | score3 | HPRD Signor | 20166139, 18669648, 10949026, ... |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000049126 (hRPS6KA2/Phos:1) | pS218,pS360,pS377,pT570 | PRO | |||
PR:000049127 (hRPS6KA2/Phos:2) | pS218,pT356,pS360,pS377,pT570,pS730 | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S106 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
T222 | M222 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
T356 | M356 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
S388 | * | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
K450 | R450 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
T471 | I471 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S546 | C546 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T574 | M574 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
T662 | M662 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
S730 | F730 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |