iPTMnet Report for Q14956 (GPNMB)
Protein Information
| UniProt AC / UniProt ID | Q14956 / GPNMB_HUMAN |
| Protein Name | Transmembrane glycoprotein NMB precursor |
| Gene Name | Name: GPNMB Synonyms:HGFIN;ORFNames:UNQ1725/PRO9925; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q14956 |
| PRO Name | transmembrane glycoprotein NMB (human) |
| Definition | A transmembrane glycoprotein NMB that is encoded in the genome of human. |
| Short Label | hGPNMB |
| Category | organism-gene |
DAG ViewQ14956 (GPNMB) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y37 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N93 | N-Glycosylation | score1 | GlyGen | 29741879 | ||
| N200 | N-Glycosylation | score2 | GlyGen UniProt | 29741879, 19159218 | ||
| Y220 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y230 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N249 | N-Glycosylation | score2 | GlyGen UniProt | 29741879, 19159218 | ||
| N275 | N-Glycosylation | score2 | GlyGen UniProt | 29741879, 19159218 | ||
| N296 | N-Glycosylation | score2 | GlyGen UniProt | 19159218 | ||
| N300 | N-Glycosylation | score2 | GlyGen UniProt | 19159218 | ||
| N306 | N-Glycosylation | score2 | GlyGen UniProt | 19159218 | ||
| T350 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S499 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S503 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K523 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y525 | Phosphorylation | score3 | PRO RLIMS-P | 26751287 | ||
| S531 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K539 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S542 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 27869121 | ||
| K549 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K559 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K564 | Ubiquitination | score1 | PhosphoSitePlus |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000047599 (hGPNMB/SigPep-/Phos:1) | pY525 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y230 | C230 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| Y230 | F230 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| N300 | D300 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| T350 | I350 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S531 | I531 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S531 | N531 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K559 | N559 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
