Protein Information

Cytoscape View

UniProt AC / UniProt ID Q14956 / GPNMB_HUMAN
Protein Name Transmembrane glycoprotein NMB precursor
Gene Name Name: GPNMB
Organism Homo sapiens (Human)

PRO ID PR:Q14956
DAG View
PRO Name transmembrane glycoprotein NMB (human)
Definition A transmembrane glycoprotein NMB that is encoded in the genome of human.
Short Label hGPNMB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q14956 (GPNMB) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
N93 N-Glycosylation GlyGen 29741879
N200 N-Glycosylation GlyGen   UniProt 29741879, 19159218
Y220 Phosphorylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
N249 N-Glycosylation GlyGen   UniProt 29741879, 19159218
N275 N-Glycosylation GlyGen   UniProt 29741879, 19159218
N296 N-Glycosylation GlyGen   UniProt 19159218
N300 N-Glycosylation GlyGen   UniProt 19159218
N306 N-Glycosylation GlyGen   UniProt 19159218
T350 O-Glycosylation GlyGen 30459171
S499 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
Y525 Phosphorylation PRO   RLIMS-P 26751287
S531 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047599 (hGPNMB/SigPep-/Phos:1) pY525 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y230 C230 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y230 F230 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
N300 D300 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T350 I350 Biomuta DOID:363 / uterine cancer [ tcga ]
S531 I531 Biomuta DOID:1612 / breast cancer [ cosmic ]
S531 N531 Biomuta DOID:363 / uterine cancer [ tcga ]