iPTMnet Report for Q14624 (ITIH4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14624 / ITIH4_HUMAN
Protein Name Inter-alpha-trypsin inhibitor heavy chain H4 precursor
Gene Name Name: ITIH4
Synonyms:IHRP,ITIHL1,PK120;ORFNames:PRO1851;
Organism Homo sapiens (Human)

PRO ID PR:Q14624
DAG View
PRO Name inter-alpha-trypsin inhibitor heavy chain H4 (human)
Definition An inter-alpha-trypsin inhibitor heavy chain H4 that is encoded in the genome of human.
Short Label hITIH4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14624 (ITIH4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R56 Methylation PhosphoSitePlus
N81 N-Glycosylation GlyGen   UniProt 16335952, 24884609, 30237853, ...19159218, 34725484, 23090970, 29391424, 29741879, 29671580
S114 Phosphorylation PhosphoSitePlus
N207 N-Glycosylation GlyGen   UniProt 16335952, 24884609, 12754519, ...29671580, 19159218
S225 Phosphorylation PhosphoSitePlus
N274 N-Glycosylation GlyGen   UniProt 24884609
S282 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
N517 N-Glycosylation GlyGen   UniProt 16335952, 24884609, 24530628, ...19159218, 23090970, 14760718, 29391424, 24279413, 29741879, 29671580
N577 N-Glycosylation GlyGen   UniProt 16335952, 24884609, 29671580, ...30237853
K626 Acetylation PhosphoSitePlus
K633 Acetylation PhosphoSitePlus
S640 O-Glycosylation GlyGen 26598643
S656 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
T701 O-Glycosylation GlyGen 30459171
S702 O-Glycosylation GlyGen 30459171
T719 O-Glycosylation GlyGen 22171320
T720 O-Glycosylation GlyGen   UniProt 30459171, 22171320
T722 O-Glycosylation GlyGen 30459171, 22171320, 26598643
T723 O-Glycosylation GlyGen 30459171, 22171320, 26598643
T725 O-Glycosylation GlyGen 30459171, 30237853, 22171320, ...26598643
S733 O-Glycosylation GlyGen 30459171, 30237853, 26598643
K831 Methylation PhosphoSitePlus
K842 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N81 N-Glycosylation PRO 24884609, 29671580
N207 N-Glycosylation PRO 24884609, 29671580
N517 N-Glycosylation PRO 24884609, 24279413, 29671580
N577 N-Glycosylation PRO 24884609, 29671580
Site PTM Type PTM Enzyme Score Source PMID
S620 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R56 Q56 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S489 L489 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T506 P506 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T506 I506 Biomuta DOID:4159 / skin cancer [ cosmic ]
T722 S722 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T723 I723 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]