Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14624 / ITIH4_HUMAN
Protein Name Inter-alpha-trypsin inhibitor heavy chain H4 precursor
Gene Name Name: ITIH4
Synonyms:IHRP,ITIHL1,PK120;ORFNames:PRO1851;
Organism Homo sapiens (Human)

PRO ID PR:Q14624
DAG View
PRO Name inter-alpha-trypsin inhibitor heavy chain H4 (human)
Definition An inter-alpha-trypsin inhibitor heavy chain H4 that is encoded in the genome of human.
Short Label hITIH4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14624 (ITIH4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R56 Methylation PhosphoSitePlus
N81 N-Glycosylation UniProt 16335952, 24884609, 19159218
S114 Phosphorylation PhosphoSitePlus
N207 N-Glycosylation UniProt 16335952, 24884609, 12754519, ...19159218
S225 Phosphorylation PhosphoSitePlus
N274 N-Glycosylation UniProt 24884609
S282 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
N517 N-Glycosylation UniProt 16335952, 24884609, 14760718, ...19159218
N577 N-Glycosylation UniProt 16335952, 24884609
K626 Acetylation PhosphoSitePlus
K633 Acetylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
T720 O-Glycosylation UniProt 22171320
K831 Methylation PhosphoSitePlus
K842 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S620 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R56 Q56 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T506 P506 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]