Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14534 / ERG1_HUMAN
Protein Name Squalene monooxygenase
Gene Name Name: SQLE
Synonyms:ERG1;
Organism Homo sapiens (Human)

PRO ID PR:Q14534
DAG View
PRO Name squalene monooxygenase (human)
Definition A squalene monooxygenase that is encoded in the genome of human.
Short Label hSQLE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14534 (SQLE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K90 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
R413 Methylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
Y566 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K90 T90 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K235 R235 Biomuta DOID:3070 / malignant glioma [ tcga ]
K363 T363 Biomuta DOID:1324 / lung cancer [ tcga ]
K433 E433 Biomuta DOID:363 / uterine cancer [ tcga ]
S567 A567 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]