iPTMnet Report for Q14240 (EIF4A2)
Protein Information
UniProt AC / UniProt ID | Q14240 / IF4A2_HUMAN |
Protein Name | Eukaryotic initiation factor 4A-II |
Gene Name | Name: EIF4A2 Synonyms:DDX2B,EIF4F; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q14240 |
PRO Name | eukaryotic initiation factor 4A-II (human) |
Definition | A eukaryotic initiation factor 4A-II that is encoded in the genome of human. |
Short Label | hEIF4A2 |
Category | organism-gene |
Q14240 (EIF4A2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y49 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y51 | Phosphorylation | score1 | PhosphoSitePlus | |||
K55 | Acetylation | score1 | PhosphoSitePlus | |||
K55 | Methylation | score1 | PhosphoSitePlus | |||
K55 | Sumoylation | score1 | PhosphoSitePlus | |||
K55 | Ubiquitination | score1 | PhosphoSitePlus | |||
C67 | Methylation | score1 | IEDB | 31844290 | ||
C67 | S-Nitrosylation | score0 | dbSNO | 24105792 | ||
K69 | Acetylation | score1 | PhosphoSitePlus | |||
K69 | Methylation | score1 | PhosphoSitePlus | |||
K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y71 | Phosphorylation | score1 | PhosphoSitePlus | |||
S79 | Phosphorylation | score1 | PhosphoSitePlus | |||
T81 | Phosphorylation | score1 | PhosphoSitePlus | |||
K83 | Ubiquitination | score1 | PhosphoSitePlus | |||
T131 | Phosphorylation | score1 | PhosphoSitePlus | |||
K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
T159 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
R169 | Methylation | score1 | PhosphoSitePlus | |||
K175 | Ubiquitination | score1 | PhosphoSitePlus | |||
S190 | Phosphorylation | score1 | PhosphoSitePlus | |||
K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y198 | Phosphorylation | score1 | PhosphoSitePlus | |||
T219 | Phosphorylation | score1 | PhosphoSitePlus | |||
K226 | Sumoylation | score1 | PhosphoSitePlus | |||
K227 | Acetylation | score1 | PhosphoSitePlus | |||
K227 | Ubiquitination | score1 | PhosphoSitePlus | |||
K239 | Ubiquitination | score1 | PhosphoSitePlus | |||
T243 | Phosphorylation | score1 | PhosphoSitePlus | |||
K248 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y251 | Phosphorylation | score1 | PhosphoSitePlus | |||
R256 | Methylation | score1 | PhosphoSitePlus | |||
K285 | Acetylation | score1 | PhosphoSitePlus | |||
K285 | Ubiquitination | score1 | PhosphoSitePlus | |||
K292 | Acetylation | score1 | PhosphoSitePlus | |||
K292 | Sumoylation | score1 | PhosphoSitePlus | |||
K292 | Ubiquitination | score1 | PhosphoSitePlus | |||
K310 | Acetylation | score1 | PhosphoSitePlus | |||
K310 | Ubiquitination | score1 | PhosphoSitePlus | |||
R317 | Methylation | score1 | PhosphoSitePlus | |||
R354 | Methylation | score1 | PhosphoSitePlus | |||
K370 | Ubiquitination | score1 | PhosphoSitePlus | |||
K382 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S5 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S2 | F2 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
S2 | A2 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S2 | C2 | Biomuta | [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
S5 | F5 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
C67 | F67 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
K69 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y71 | H71 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K147 | T147 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
T159 | I159 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y198 | F198 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
K227 | Q227 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K239 | T239 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K285 | R285 | Biomuta | [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] |