Protein Information

Cytoscape View

UniProt AC / UniProt ID Q14240 / IF4A2_HUMAN
Protein Name Eukaryotic initiation factor 4A-II
Gene Name Name: EIF4A2
Organism Homo sapiens (Human)

PRO ID PR:Q14240
DAG View
PRO Name eukaryotic initiation factor 4A-II (human)
Definition A eukaryotic initiation factor 4A-II that is encoded in the genome of human.
Short Label hEIF4A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q14240 (EIF4A2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Methylation PhosphoSitePlus
K55 Sumoylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
C67 S-Nitrosylation dbSNO 24105792
K69 Acetylation PhosphoSitePlus
K69 Methylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus   UniProt 23186163
R169 Methylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
K226 Sumoylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
R256 Methylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K292 Acetylation PhosphoSitePlus
K292 Sumoylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K310 Acetylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
R317 Methylation PhosphoSitePlus
R354 Methylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T219 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta DOID:1324 / lung cancer [ tcga ]
S2 A2 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y71 H71 Biomuta DOID:363 / uterine cancer [ tcga ]
K147 T147 Biomuta DOID:363 / uterine cancer [ tcga ]
Y198 F198 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K227 Q227 Biomuta DOID:1909 / melanoma [ cosmic ]
K239 R239 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R256 T256 Biomuta DOID:1612 / breast cancer [ tcga ]
K285 R285 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]