iPTMnet Report for Q14240 (EIF4A2)
Protein Information
| UniProt AC / UniProt ID | Q14240 / IF4A2_HUMAN |
| Protein Name | Eukaryotic initiation factor 4A-II |
| Gene Name | Name: EIF4A2 Synonyms:DDX2B,EIF4F; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q14240 |
| PRO Name | eukaryotic initiation factor 4A-II (human) |
| Definition | A eukaryotic initiation factor 4A-II that is encoded in the genome of human. |
| Short Label | hEIF4A2 |
| Category | organism-gene |
Q14240 (EIF4A2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y49 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y51 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K55 | Acetylation | score1 | PhosphoSitePlus | |||
| K55 | Methylation | score1 | PhosphoSitePlus | |||
| K55 | Sumoylation | score1 | PhosphoSitePlus | |||
| K55 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C67 | Methylation | score1 | IEDB | 31844290 | ||
| C67 | S-Nitrosylation | score0 | dbSNO | 24105792 | ||
| K69 | Acetylation | score1 | PhosphoSitePlus | |||
| K69 | Methylation | score1 | PhosphoSitePlus | |||
| K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y71 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S79 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T81 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K83 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T131 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T159 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| R169 | Methylation | score1 | PhosphoSitePlus | |||
| K175 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S190 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y198 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T219 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K226 | Sumoylation | score1 | PhosphoSitePlus | |||
| K227 | Acetylation | score1 | PhosphoSitePlus | |||
| K227 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K239 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T243 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K248 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y251 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R256 | Methylation | score1 | PhosphoSitePlus | |||
| K285 | Acetylation | score1 | PhosphoSitePlus | |||
| K285 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K292 | Acetylation | score1 | PhosphoSitePlus | |||
| K292 | Sumoylation | score1 | PhosphoSitePlus | |||
| K292 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K310 | Acetylation | score1 | PhosphoSitePlus | |||
| K310 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R317 | Methylation | score1 | PhosphoSitePlus | |||
| R354 | Methylation | score1 | PhosphoSitePlus | |||
| K370 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K382 | Ubiquitination | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S5 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S2 | F2 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S2 | A2 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S2 | C2 | Biomuta | [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| S5 | F5 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| C67 | F67 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| K69 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y71 | H71 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K147 | T147 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T159 | I159 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y198 | F198 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| K227 | Q227 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K239 | T239 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K285 | R285 | Biomuta | [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] |
DAG View