iPTMnet Report for Q13769 (THOC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13769 / THOC5_HUMAN
Protein Name THO complex subunit 5 homolog
Gene Name Name: THOC5
Synonyms:C22orf19,KIAA0983;
Organism Homo sapiens (Human)

PRO ID PR:Q13769
DAG View
PRO Name THO complex subunit 5 homolog (human)
Definition A THO complex subunit 5 that is encoded in the genome of human.
Short Label hTHOC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13769 (THOC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 O-Glycosylation GlyGen 30379171, 34019948
S2 Phosphorylation HPRD 20068231
S3 Phosphorylation HPRD 20068231
S5 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   Signor 15221008
S6 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   Signor 15221008, 20068231
S16 Phosphorylation HPRD   PhosphoSitePlus 20068231
K24 Acetylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
S74 O-Glycosylation GlyGen 30379171, 34019948
K146 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
Y225 Phosphorylation P09619 (PDGFRB) PhosphoSitePlus   RLIMS-P   UniProt 18373705, 26919114, 23032722
S293 Phosphorylation PhosphoSitePlus
S307 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 21406692, 18452278, ...18669648, 24275569, 20166139, 19690332, 20068231
S312 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 17525332, 18452278, 19651622, 18669648, 19415658, 24275569, 20166139, 19690332, 20068231
S314 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17525332, 23186163, ...17081983, 21406692, 18452278, 19651622, 18669648, 19690332, 24275569, 20166139, 19415658, 20068231
T321 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T322 Phosphorylation HPRD   phospho.ELM 18669648
T328 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
K336 Ubiquitination PhosphoSitePlus
S347 Phosphorylation HPRD   PhosphoSitePlus 20068231
K412 Ubiquitination PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
C630 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 L5 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y37 C37 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K146 N146 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K217 N217 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T322 M322 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T322 A322 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y420 S420 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]