Protein Information

Cytoscape View

UniProt AC / UniProt ID Q13761 / RUNX3_HUMAN
Protein Name Runt-related transcription factor 3
Gene Name Name: RUNX3
Organism Homo sapiens (Human)

PRO ID PR:Q13761
DAG View
PRO Name runt-related transcription factor 3 (human)
Definition A runt-related transcription factor 3 that is encoded in the genome of human.
Short Label hRUNX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q13761 (RUNX3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus 18767071
S149 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
T151 Phosphorylation PhosphoSitePlus 18767071
T151 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
T153 Phosphorylation PhosphoSitePlus 18767071
T153 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
T155 Phosphorylation PhosphoSitePlus 18767071
T155 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
K171 Acetylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus   RLIMS-P 27217562
K186 Ubiquitination PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K192 Sumoylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
T212 O-Glycosylation GlyGen 29351928
T212 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
R216 Methylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
S237 O-Glycosylation GlyGen 29351928
S243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
S251 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S261 O-Glycosylation GlyGen 29351928
S261 Phosphorylation PhosphoSitePlus
R262 Methylation PhosphoSitePlus
R267 Methylation PhosphoSitePlus
S281 O-Glycosylation GlyGen 29351928
T283 O-Glycosylation GlyGen 29351928
S285 O-Glycosylation GlyGen 29351928
S288 O-Glycosylation GlyGen 29351928
S293 O-Glycosylation GlyGen 29351928
S301 O-Glycosylation GlyGen 29351928
R302 Methylation PhosphoSitePlus
S320 O-Glycosylation GlyGen 29351928
S328 O-Glycosylation GlyGen 29351928
S356 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 31015486, 19351720
S356 Phosphorylation P11802 (CDK4) neXtProt   PhosphoSitePlus   Signor 19351720

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 F17 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K94 E94 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T173 I173 Biomuta DOID:1909 / melanoma [ cosmic ]
R216 Q216 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
S220 G220 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R267 M267 Biomuta DOID:1909 / melanoma [ cosmic ]
S285 P285 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S285 L285 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S288 R288 Biomuta DOID:3571 / liver cancer [ icgc ]
R302 L302 Biomuta DOID:1324 / lung cancer [ tcga ]
S328 F328 Biomuta DOID:1909 / melanoma [ icgc, tcga ]