iPTMnet Report for Q13761 (RUNX3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13761 / RUNX3_HUMAN
Protein Name Runt-related transcription factor 3
Gene Name Name: RUNX3
Synonyms:AML2,CBFA3,PEBP2A3;
Organism Homo sapiens (Human)

PRO ID PR:Q13761
DAG View
PRO Name runt-related transcription factor 3 (human)
Definition A runt-related transcription factor 3 that is encoded in the genome of human.
Short Label hRUNX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13761 (RUNX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K129 Methylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S149 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
T151 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
T153 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
T155 Phosphorylation P11309 (PIM1) PhosphoSitePlus 18767071
K171 Acetylation PhosphoSitePlus
K171 Methylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus   RLIMS-P 27217562
K186 Ubiquitination PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K192 Sumoylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
T212 O-Glycosylation GlyGen 29351928
T212 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
R216 Methylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
S237 O-Glycosylation GlyGen 29351928
S243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
S251 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S261 O-Glycosylation GlyGen 29351928
S261 Phosphorylation PhosphoSitePlus
R262 Methylation PhosphoSitePlus
R267 Methylation PhosphoSitePlus
S281 O-Glycosylation GlyGen 29351928
T283 O-Glycosylation GlyGen 29351928
S285 O-Glycosylation GlyGen 29351928
S288 O-Glycosylation GlyGen 29351928
S293 O-Glycosylation GlyGen 29351928
S301 O-Glycosylation GlyGen 29351928
R302 Methylation PhosphoSitePlus
S320 O-Glycosylation GlyGen 29351928
S328 O-Glycosylation GlyGen 29351928
S356 Phosphorylation P11802 (CDK4) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 31015486, 19351720


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 F17 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K94 E94 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K148 N148 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K171 N171 Biomuta DOID:4159 / skin cancer [ cosmic ]
T173 I173 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S214 G214 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R216 Q216 Biomuta DOID:1319 / brain cancer [ cosmic ]
R216 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S220 N220 Biomuta DOID:4159 / skin cancer [ cosmic ]
S220 G220 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T254 M254 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R262 H262 Biomuta DOID:4159 / skin cancer [ cosmic ]
R267 G267 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R267 M267 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T283 M283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T283 K283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T283 Q283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T283 P283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S285 L285 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S285 P285 Biomuta DOID:3571 / liver cancer [ cosmic ]
S288 N288 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R302 L302 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S328 F328 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]