Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13621 / S12A1_HUMAN
Protein Name Solute carrier family 12 member 1
Gene Name Name: SLC12A1
Synonyms:NKCC2;
Organism Homo sapiens (Human)

PRO ID PR:Q13621
DAG View
PRO Name solute carrier family 12 member 1 (human)
Definition A solute carrier family 12 member 1 that is encoded in the genome of human.
Short Label hSLC12A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13621 (SLC12A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y70 Phosphorylation PhosphoSitePlus
S91 Phosphorylation Q9UEW8 (STK39) PhosphoSitePlus   RLIMS-P   Signor 21321328
T95 Phosphorylation Q9UEW8 (STK39) , O95747 (OXSR1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21423148, 21321328, 20091762
T100 Phosphorylation Q9BYP7 (WNK3) , O95747 (OXSR1) , Q9UEW8 (STK39) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 16275913, 21423148, 21321328, ...20091762
T105 Phosphorylation O95747 (OXSR1) , Q9BYP7 (WNK3) , Q9UEW8 (STK39) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 16275913, 21423148, 21321328, ...20091762
T118 Phosphorylation O95747 (OXSR1) PhosphoSitePlus 21423148
S120 Phosphorylation O95747 (OXSR1) PhosphoSitePlus 21423148
S122 Phosphorylation Q13131 (PRKAA1) neXtProt 17341212
S130 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 30248150, 21321328, 19176702
Y245 Phosphorylation PhosphoSitePlus
K722 Methylation PhosphoSitePlus
K735 Methylation PhosphoSitePlus
Y944 Phosphorylation PhosphoSitePlus
S1056 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T118 I118 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
S120 I120 Biomuta DOID:3571 / liver cancer [ icgc ]
S122 I122 Biomuta DOID:1115 / sarcoma [ tcga ]
S1056 I1056 Biomuta DOID:1115 / sarcoma [ tcga ]
S1056 N1056 Biomuta DOID:363 / uterine cancer [ tcga ]