iPTMnet Report for Q13569 (TDG)
Protein Information
UniProt AC / UniProt ID | Q13569 / TDG_HUMAN |
Protein Name | G/T mismatch-specific thymine DNA glycosylase |
Gene Name | Name: TDG |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q13569 |
PRO Name | G/T mismatch-specific thymine DNA glycosylase (human) |
Definition | A G/T mismatch-specific thymine DNA glycosylase that is encoded in the genome of human. |
Short Label | hTDG |
Category | organism-gene |
Q13569 (TDG) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
S82 | Phosphorylation | score1 | PhosphoSitePlus | |||
K83 | Acetylation | score1 | PhosphoSitePlus | |||
K84 | Acetylation | score1 | PhosphoSitePlus | |||
S85 | Phosphorylation | score1 | PhosphoSitePlus | |||
K87 | Acetylation | score1 | PhosphoSitePlus | |||
K92 | Acetylation | score1 | PhosphoSitePlus | |||
K94 | Acetylation | score1 | PhosphoSitePlus | |||
K97 | Acetylation | score1 | PhosphoSitePlus | |||
K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y185 | Phosphorylation | score1 | PhosphoSitePlus | |||
K201 | Ubiquitination | score1 | PhosphoSitePlus | |||
K206 | Ubiquitination | score1 | PhosphoSitePlus | |||
K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
S239 | Phosphorylation | score1 | PhosphoSitePlus | |||
K246 | Ubiquitination | score1 | PhosphoSitePlus | |||
K248 | Sumoylation | score1 | PhosphoSitePlus | |||
K248 | Ubiquitination | score1 | PhosphoSitePlus | |||
K258 | Ubiquitination | score1 | PhosphoSitePlus | |||
C276 | Methylation | score1 | IEDB | 31844290 | ||
K285 | Ubiquitination | score1 | PhosphoSitePlus | |||
K300 | Ubiquitination | score1 | PhosphoSitePlus | |||
K330 | Sumoylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K84 | T84 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S85 | P85 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S85 | F85 | Biomuta | [ cosmic ] | |
K94 | R94 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K94 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y185 | N185 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K201 | T201 | Biomuta | DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
K258 | N258 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K300 | E300 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |