Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13569 / TDG_HUMAN
Protein Name G/T mismatch-specific thymine DNA glycosylase
Gene Name Name: TDG
Organism Homo sapiens (Human)

PRO ID PR:Q13569
DAG View
PRO Name G/T mismatch-specific thymine DNA glycosylase (human)
Definition A G/T mismatch-specific thymine DNA glycosylase that is encoded in the genome of human.
Short Label hTDG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13569 (TDG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K71 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K248 Sumoylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K330 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S85 P85 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K94 R94 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K94 * Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y185 N185 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K201 T201 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
K258 N258 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K300 E300 Biomuta DOID:363 / uterine cancer [ tcga ]