iPTMnet Report for Q13569 (TDG)
Protein Information
| UniProt AC / UniProt ID | Q13569 / TDG_HUMAN |
| Protein Name | G/T mismatch-specific thymine DNA glycosylase |
| Gene Name | Name: TDG |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q13569 |
| PRO Name | G/T mismatch-specific thymine DNA glycosylase (human) |
| Definition | A G/T mismatch-specific thymine DNA glycosylase that is encoded in the genome of human. |
| Short Label | hTDG |
| Category | organism-gene |
Q13569 (TDG) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S82 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K83 | Acetylation | score1 | PhosphoSitePlus | |||
| K84 | Acetylation | score1 | PhosphoSitePlus | |||
| S85 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K87 | Acetylation | score1 | PhosphoSitePlus | |||
| K92 | Acetylation | score1 | PhosphoSitePlus | |||
| K94 | Acetylation | score1 | PhosphoSitePlus | |||
| K97 | Acetylation | score1 | PhosphoSitePlus | |||
| K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y185 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K201 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K206 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S239 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K246 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K248 | Sumoylation | score1 | PhosphoSitePlus | |||
| K248 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K258 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C276 | Methylation | score1 | IEDB | 31844290 | ||
| K285 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K300 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K330 | Sumoylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K84 | T84 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S85 | P85 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S85 | F85 | Biomuta | [ cosmic ] | |
| K94 | R94 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K94 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y185 | N185 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K201 | T201 | Biomuta | DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
| K258 | N258 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K300 | E300 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
DAG View