iPTMnet Report for Q13568 (IRF5)
Protein Information
| UniProt AC / UniProt ID | Q13568 / IRF5_HUMAN |
| Protein Name | Interferon regulatory factor 5 |
| Gene Name | Name: IRF5 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q13568 |
| PRO Name | interferon regulatory factor 5 (human) |
| Definition | An interferon regulatory factor 5 that is encoded in the genome of human. |
| Short Label | hIRF5 |
| Category | organism-gene |
DAG ViewQ13568 (IRF5) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T10 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 22412986 | ||
| C44 | Methylation | score1 | IEDB | 31844290 | ||
| Y136 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S158 | Phosphorylation | score3 | PhosphoSitePlus Signor UniProt | 22412986 | ||
| S158 | Phosphorylation | Q9UHD2 (TBK1) | score3 | PhosphoSitePlus Signor | 22412986 | |
| C272 | Methylation | score1 | IEDB | 31844290 | ||
| S293 | Phosphorylation | score3 | PhosphoSitePlus Signor UniProt | 22412986 | ||
| S293 | Phosphorylation | Q9UHD2 (TBK1) | score3 | PhosphoSitePlus Signor | 22412986 | |
| S301 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 22412986 | ||
| K309 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y313 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y335 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C357 | Methylation | score1 | IEDB | 31844290 | ||
| K411 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 18824541 | ||
| K412 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 18824541 | ||
| S431 | O-Glycosylation | score2 | GlyGen | 32494619 | ||
| S435 | Phosphorylation | score4 | PhosphoSitePlus Signor UniProt | 22412986, 18836453 | ||
| S435 | Phosphorylation | O43353 (RIPK2) | score1 | Signor | 22412986 | |
| S437 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 31024565, 18836453 | ||
| S440 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 18836453 | ||
| S446 | Phosphorylation | score4 | PhosphoSitePlus Signor UniProt | 22412986, 25326418, 18836453 | ||
| S446 | Phosphorylation | O14920 (IKBKB) | score2 | PhosphoSitePlus | 25326418 | |
| S446 | Phosphorylation | O43353 (RIPK2) | score1 | Signor | 22412986 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T10 | P10 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S158 | N158 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K412 | Q412 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K412 | N412 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
