Protein Information

Cytoscape View

UniProt AC / UniProt ID Q13568 / IRF5_HUMAN
Protein Name Interferon regulatory factor 5
Gene Name Name: IRF5
Organism Homo sapiens (Human)

PRO ID PR:Q13568
DAG View
PRO Name interferon regulatory factor 5 (human)
Definition An interferon regulatory factor 5 that is encoded in the genome of human.
Short Label hIRF5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q13568 (IRF5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus   UniProt 22412986
Y136 Phosphorylation PhosphoSitePlus
S158 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus   Signor   UniProt 22412986
S293 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus   Signor   UniProt 22412986
S301 Phosphorylation PhosphoSitePlus   UniProt 22412986
K309 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
Y335 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus   UniProt 18824541
K412 Ubiquitination PhosphoSitePlus   UniProt 18824541
S435 Phosphorylation O43353 (RIPK2) PhosphoSitePlus   Signor   UniProt 22412986, 18836453
S437 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31024565, 18836453
S440 Phosphorylation PhosphoSitePlus   UniProt 18836453
S446 Phosphorylation O14920 (IKBKB) , O43353 (RIPK2) PhosphoSitePlus   Signor   UniProt 22412986, 25326418, 18836453

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T10 P10 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
S158 N158 Biomuta DOID:363 / uterine cancer [ tcga ]
S301 I301 Biomuta DOID:3571 / liver cancer [ icgc ]
Y313 C313 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y335 * Biomuta DOID:1115 / sarcoma [ tcga ]
K412 R412 Biomuta DOID:2531 / hematologic cancer [ icgc ]