iPTMnet Report for Q13561 (DCTN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13561 / DCTN2_HUMAN
Protein Name Dynactin subunit 2
Gene Name Name: DCTN2
Synonyms:DCTN50;
Organism Homo sapiens (Human)

PRO ID PR:Q13561
DAG View
PRO Name dynactin subunit 2 (human)
Definition A dynactin subunit 2 that is encoded in the genome of human.
Short Label hDCTN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13561 (DCTN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K5 Ubiquitination PhosphoSitePlus
Y6 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
Y54 Phosphorylation PhosphoSitePlus
K65 Methylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
R72 Methylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
Y86 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus   UniProt 23186163
K140 Ubiquitination PhosphoSitePlus
K146 Acetylation IEDB 34357683
K146 Ubiquitination PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus   UniProt 23186163
S202 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K308 Acetylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation HPRD 15144186, 20068231, 18707149
T84 Phosphorylation HPRD 18669648, 20068231
S88 Phosphorylation HPRD 18669648, 15345747, 20068231
Y91 Phosphorylation HPRD 19901323
T203 Phosphorylation HPRD 20068231
T265 Phosphorylation HPRD 20068231
T320 Phosphorylation HPRD 15570572


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K65 R65 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
R72 H72 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R72 C72 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T98 I98 Biomuta DOID:4159 / skin cancer [ cosmic ]
T98 A98 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K102 E102 Biomuta DOID:1319 / brain cancer [ icgc ]
S127 L127 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T198 S198 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T203 S203 Biomuta DOID:2531 / hematologic cancer [ cosmic ]