iPTMnet Report for Q13541 (EIF4EBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13541 / 4EBP1_HUMAN
Protein Name Eukaryotic translation initiation factor 4E-binding protein 1
Gene Name Name: EIF4EBP1
Organism Homo sapiens (Human)

PRO ID PR:Q13541
DAG View
PRO Name eukaryotic translation initiation factor 4E-binding protein 1 (human)
Definition A eukaryotic translation initiation factor 4E-binding protein 1 that is encoded in the genome of human.
Short Label hEIF4EBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13541 (EIF4EBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378, 12665801
S2 Phosphorylation PhosphoSitePlus
S5 O-Glycosylation GlyGen 23301498, 31373491, 33801653
S5 Phosphorylation PhosphoSitePlus
S6 O-Glycosylation GlyGen 23301498, 31373491, 33801653
S6 Phosphorylation RLIMS-P 26259639, 33471625, 20863555, ...34930349
S8 Phosphorylation phospho.ELM   PhosphoSitePlus 10713094
S8 Phosphorylation Q13315 (ATM) phospho.ELM 10713094
T10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18669648, 20068231
S35 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19664995, 20068231
T36 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20736160, 30397197, 18220336, ...10471835, 20227039, 9465032, 18669648, 17510057, 11777913, 10405182, 20068231
T36 Phosphorylation O75582 (RPS6KA5) HPRD   neXtProt 11777913, 18669648, 20068231
T36 Phosphorylation P31751 (AKT2) neXtProt 20227039
T36 Phosphorylation P42345 (MTOR) Signor 9465032, 17510057
T36 Phosphorylation P51449 (RORC) HPRD 11777913, 18669648, 20068231
T37 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11777913, 28252104, 28272965, ...31046771, 20804212, 22039466, 26472029, 12747827, 19651622, 21132000, 33038921, 24586775, 27402756, 22578813, 29750193, 23584478, 24384983, 16873412, 11691836, 26832959, 18701453, 19036825, 24159375, 20711498, 19367274, 23186163, 33191406, 29236692, 16825247, 28539821, 22421144, 29795412, 19487463, 18577697, 12370290, 30602778, 20068231, 19690332, 24923301, 35697076, 31717924, 20616057, 23814053, 31073371, 10364159, 19413330, 27048233, 24358826, 20537536, 10942774, 19346248, 31201269, 33742064, 25486193, 29357370, 28915586, 21320304, 29472733, 31641103, 24970798, 31122207, 18365020, 9465032, 19331694, 30698812, 30397197, 27387559, 21837706, 25961827, 18701920, 19664995, 31138781, 30931929, 22253983, 18669648, 25673820, 17386266, 29423932, 21659604, 32075852, 29233971
T37 Phosphorylation P06493 (CDK1) RLIMS-P+ 27402756
T37 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus   Signor 11777913, 19413330, 10942774, ...19664995, 19651622, 18669648, 11691836, 20068231
T37 Phosphorylation P31749 (AKT1) HPRD 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
T37 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   Signor 11777913, 20804212, 19413330, ...17386266, 19346248, 10942774, 19664995, 9465032, 12370290, 20068231, 21659604, 20537536, 12747827, 18669648, 19651622
T37 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 18701453, 23584478
T37 Phosphorylation Q16539 (MAPK14) HPRD   neXtProt   Signor 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
T37 Phosphorylation Q5S007 (LRRK2) neXtProt 18701920
T41 Phosphorylation HPRD   PhosphoSitePlus   Signor   UniProt 19413330, 23186163, 24247720, ...19651622, 18669648, 21659604, 20068231
T41 Phosphorylation P42345 (MTOR) PhosphoSitePlus 21659604
T41 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus   Signor 24247720
S44 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19651622, 18669648, ...21659604, 20068231
S44 Phosphorylation P42345 (MTOR) PhosphoSitePlus 21659604
T45 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20736160, 19413330, 11799119, ...18220336, 20227039, 9465032, 18669648, 17510057, 11777913, 10405182, 20068231
T45 Phosphorylation O75582 (RPS6KA5) HPRD   neXtProt 11777913, 19413330, 18669648, ...20068231
T45 Phosphorylation P28482 (MAPK1) Signor 11777913
T45 Phosphorylation P31751 (AKT2) neXtProt 20227039
T45 Phosphorylation P42345 (MTOR) Signor 9465032, 17510057
T45 Phosphorylation P51449 (RORC) HPRD 11777913, 19413330, 18669648, ...20068231
T46 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11777913, 28252104, 28272965, ...31046771, 25020061, 20804212, 22421144, 26472029, 10942774, 21132000, 33038921, 24586775, 27402756, 22578813, 29750193, 23584478, 24384983, 16873412, 11691836, 26832959, 18701453, 19036825, 24159375, 20711498, 19367274, 33191406, 29236692, 16249273, 20537536, 28539821, 22039466, 29795412, 19487463, 18577697, 21837706, 12370290, 30602778, 20068231, 12747827, 35697076, 31717924, 20616057, 23814053, 19690332, 10364159, 19413330, 27048233, 17386266, 24358826, 29357370, 36882522, 19346248, 31201269, 33742064, 9465032, 24923301, 28915586, 21320304, 29472733, 31641103, 24970798, 19651622, 18365020, 25486193, 19331694, 32021427, 30397197, 27387559, 22253983, 25961827, 19664995, 31138781, 31073371, 30698812, 18669648, 25673820, 18701920, 29423932, 30931929, 32075852, 29233971
T46 Phosphorylation P06493 (CDK1) RLIMS-P+ 27402756
T46 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus   Signor 11777913, 19413330, 10942774, ...19664995, 19651622, 18669648, 11691836, 20068231
T46 Phosphorylation P31749 (AKT1) HPRD 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
T46 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   Signor 11777913, 19413330, 9465032, ...20804212, 17386266, 19346248, 10942774, 18669648, 19664995, 19651622, 12370290, 20537536, 12747827, 20068231
T46 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 18701453, 23584478
T46 Phosphorylation Q14004 (CDK13) Signor 36882522
T46 Phosphorylation Q16539 (MAPK14) HPRD   neXtProt   Signor 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
T46 Phosphorylation Q5S007 (LRRK2) neXtProt 18701920
T50 Phosphorylation HPRD   PhosphoSitePlus   Signor   UniProt 18669648, 24247720, 17081983, ...18220336
T50 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus   Signor 24247720
Y54 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
K57 Ubiquitination PhosphoSitePlus   UniProt 22578813
C62 S-Nitrosylation dbSNO 24105792
R63 Methylation PhosphoSitePlus
S65 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11777913, 28272965, 27056897, ...11553333, 10942774, 24205284, 12869584, 33038921, 27402756, 12912989, 22578813, 29750193, 24931163, 29233971, 11691836, 26832959, 17081983, 20068231, 30931929, 25702871, 23186163, 33191406, 16825247, 12860993, 22421144, 29795412, 19487463, 12588975, 22808163, 30602778, 16123140, 24275569, 24923301, 35697076, 24970798, 20616057, 23814053, 29507660, 31284427, 33130472, 22657251, 18767875, 31201269, 24466059, 25486193, 29357370, 33658483, 27055259, 28915586, 22267338, 24316235, 17287340, 8083223, 31122207, 28903425, 19651622, 19331694, 24562770, 25999352, 20880835, 27387559, 25880415, 25961827, 20170512, 12105188, 19664995, 31138781, 27065332, 11278829, 31073371, 18669648, 26434594, 12054859, 32075852, 12747827
S65 Phosphorylation O75582 (RPS6KA5) HPRD   neXtProt 11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
S65 Phosphorylation P06493 (CDK1) RLIMS-P+ 27402756
S65 Phosphorylation P27361 (MAPK3) neXtProt   PhosphoSitePlus 11553333
S65 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus   Signor 11777913, 17287340, 18767875, ...10942774, 19664995, 8083223, 19651622, 18669648, 11691836, 20068231
S65 Phosphorylation P31749 (AKT1) HPRD 11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
S65 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   Signor 11777913, 17287340, 18767875, ...10942774, 19664995, 19651622, 18669648, 12747827, 12912989, 20068231
S65 Phosphorylation Q16539 (MAPK14) HPRD   neXtProt   Signor 11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
S65 Phosphorylation Q8TAI7 (RHEBL1) HPRD 11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
S65 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus 12588975
S65 Phosphorylation Q9P1W9 (PIM2) neXtProt 16123140, 12869584
T68 O-Glycosylation GlyGen 23301498, 31373491, 33801653
T68 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
K69 Ubiquitination PhosphoSitePlus
T70 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11777913, 20142804, 25762619, ...11553333, 10942774, 21132000, 33038921, 27402756, 28272965, 28213783, 29750193, 29233971, 11691836, 26832959, 28475412, 19651622, 22808163, 21406692, 23186163, 33191406, 16825247, 12860993, 22421144, 29795412, 19487463, 30931929, 23340172, 12370290, 30602778, 24275569, 25527453, 12747827, 24970798, 27065332, 12912989, 11410517, 18220336, 31201269, 31867267, 25702871, 28915586, 19804365, 24605337, 31122207, 30397197, 25486193, 19331694, 17287340, 17081983, 27387559, 29845289, 25961827, 19664995, 18669648, 32075852, 12054859, 22578813, 24358826, 20068231
T70 Phosphorylation P06493 (CDK1) PhosphoSitePlus   RLIMS-P+   Signor 11553333, 27402756
T70 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus   Signor 17287340, 10942774, 19664995, ...19651622, 18669648, 12747827, 11691836, 20068231
T70 Phosphorylation P41279 (MAP3K8) PhosphoSitePlus 19804365
T70 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   Signor 17287340, 10942774, 19664995, ...12912989, 19651622, 12370290, 12747827, 18669648, 20068231
T70 Phosphorylation Q16539 (MAPK14) neXtProt 11777913
T77 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18669648, 24275569
T82 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S83 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10779345, 9204908, 31201269, ...9405468, 30931929, 27402756, 18669648, 9092573, 11691836
S83 Phosphorylation P06493 (CDK1) RLIMS-P+ 27402756
S83 Phosphorylation P28482 (MAPK1) HPRD   Signor 10779345, 18669648, 11691836, ...9092573, 9405468
S83 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   Signor 10779345, 9204908, 18669648, ...9092573, 9405468
S85 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S86 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17081983
S94 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus 10608806, 17287340, 17081983, ...18669648, 20068231
S94 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus 10608806
S94 Phosphorylation Q13535 (ATR) neXtProt 10608806
S96 Phosphorylation HPRD 17081983
S101 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 17287340, 18220336, 31201269, ...12588975, 19651622, 23186163, 24358826, 12912989, 20068231
S101 Phosphorylation P42345 (MTOR) phospho.ELM 12912989
S101 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus 12588975
S112 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11146653, 17525332, 23186163, ...18212344, 21406692, 12588975, 9806882
S112 Phosphorylation P19784 (CSNK2A2) HPRD   Signor 11146653, 9806882, 18212344, ...12588975
S112 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 11146653, 9806882, 18212344, ...12588975
S112 Phosphorylation Q13315 (ATM) HPRD   phospho.ELM   Signor 11146653, 9806882, 18212344, ...12588975
Site PTM Type PTM Enzyme Score Source PMID
T37 Phosphorylation PRO
T46 Phosphorylation PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044854 (hEIF4EBP1/InitMet-/AcPhos:1) pS94 PRO
PR:000044855 (hEIF4EBP1/InitMet-/AcPhos:2) pS94,pS101 PRO
PR:000026216 (hEIF4EBP1/iso:1/Phos:1) pT37,pT46 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13541 (EIF4EBP1) T36 P06730 (EIF4E) inhibited_association eFIP 10405182
Phosphorylation Q13541 (EIF4EBP1) S65 P06730 (EIF4E) increased_association eFIP 31138781
Phosphorylation Q13541 (EIF4EBP1) T70 P06730 (EIF4E) inhibited_association eFIP 31201269
Phosphorylation Q13541 (EIF4EBP1) T37 P06730 (EIF4E) inhibited_association eFIP 24358826
Phosphorylation Q13541 (EIF4EBP1) T70 P06730 (EIF4E) inhibited_association eFIP 12054859


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T41 S41 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y54 N54 Biomuta DOID:3571 / liver cancer [ cosmic ]
R63 Q63 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R63 W63 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S85 F85 Biomuta [ cosmic ]
S86 N86 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S101 C101 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]