Protein Information

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UniProt AC / UniProt ID Q13541 / 4EBP1_HUMAN
Protein Name Eukaryotic translation initiation factor 4E-binding protein 1
Gene Name Name: EIF4EBP1
Organism Homo sapiens (Human)

PRO ID PR:Q13541
DAG View
PRO Name eukaryotic translation initiation factor 4E-binding protein 1 (human)
Definition A eukaryotic translation initiation factor 4E-binding protein 1 that is encoded in the genome of human.
Short Label hEIF4EBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13541 (EIF4EBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378, 12665801
S2 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S6 Phosphorylation RLIMS-P 30023463, 20863555, 24130864, ...25261369, 26259639, 33471625
S8 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus 10713094
T10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18669648, 20068231
S35 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19664995, 20068231
T36 Phosphorylation P51449 (RORC) , O75582 (RPS6KA5) , P31751 (AKT2) , P42345 (MTOR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20736160, 30397197, 18220336, ...10471835, 20227039, 9465032, 18669648, 17510057, 11777913, 10405182, 20068231
T37 Phosphorylation P49841 (GSK3B) , Q16539 (MAPK14) , P31749 (AKT1) , P42345 (MTOR) , P06493 (CDK1) , P28482 (MAPK1) , Q5S007 (LRRK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 28272965, 26472029, 21132000, ...24586775, 32188029, 11691836, 18577697, 20537536, 22421144, 19487463, 12370290, 21659604, 29357370, 28881582, 30698812, 20804212, 23584478, 28915586, 29472733, 24970798, 19331694, 31878201, 30397197, 19664995, 22253983, 29423932, 11777913, 28252104, 33507584, 33038921, 29750193, 26832959, 20711498, 32603377, 24159375, 31717924, 31073371, 27048233, 18701920, 23082216, 27387559, 31138781, 25673820, 33742064, 20068231, 10942774, 22578813, 23186163, 16825247, 28539821, 30931929, 12747827, 20616057, 23814053, 19690332, 10364159, 19346248, 19651622, 24923301, 21320304, 31641103, 18365020, 21837706, 18669648, 31046771, 27402756, 24384983, 16873412, 29233971, 19036825, 33191406, 22039466, 29795412, 30602778, 18701453, 25961827, 19413330, 31201269, 9465032, 19367274, 31122207, 25486193, 17386266, 32075852, 24358826
T41 Phosphorylation P42345 (MTOR) , P49674 (CSNK1E) HPRD   PhosphoSitePlus   Signor   UniProt 19413330, 23186163, 24247720, ...19651622, 18669648, 21659604, 20068231
S44 Phosphorylation P42345 (MTOR) HPRD   PhosphoSitePlus 19413330, 19651622, 18669648, ...21659604, 20068231
T45 Phosphorylation O75582 (RPS6KA5) , P42345 (MTOR) , P28482 (MAPK1) , P31751 (AKT2) , P51449 (RORC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20736160, 19413330, 11799119, ...18220336, 20227039, 9465032, 18669648, 17510057, 11777913, 10405182, 20068231
T46 Phosphorylation P06493 (CDK1) , Q5S007 (LRRK2) , Q16539 (MAPK14) , P42345 (MTOR) , P31749 (AKT1) , P28482 (MAPK1) , P49841 (GSK3B) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11777913, 28252104, 28272965, ...31046771, 25020061, 20804212, 22421144, 26472029, 10942774, 21132000, 33038921, 24586775, 27402756, 22578813, 29750193, 32188029, 30931929, 24384983, 16873412, 11691836, 26832959, 33507584, 19036825, 18577697, 20711498, 19367274, 33191406, 16249273, 32603377, 28539821, 22039466, 29795412, 19487463, 24159375, 21837706, 12370290, 30602778, 20068231, 12747827, 18701453, 31717924, 20616057, 23814053, 19690332, 10364159, 19413330, 27048233, 17386266, 24358826, 20537536, 29357370, 19346248, 31201269, 23584478, 33742064, 9465032, 24923301, 28915586, 21320304, 23082216, 29472733, 31641103, 24970798, 19651622, 18365020, 25486193, 19331694, 32021427, 31878201, 30397197, 28881582, 22253983, 25961827, 19664995, 31138781, 31073371, 30698812, 18669648, 25673820, 18701920, 29423932, 27387559, 32075852, 29233971
T50 Phosphorylation P49674 (CSNK1E) HPRD   PhosphoSitePlus   Signor   UniProt 18669648, 24247720, 17081983, ...18220336
Y54 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
K57 Ubiquitination PhosphoSitePlus   UniProt 22578813
C62 S-Nitrosylation dbSNO 24105792
R63 Methylation PhosphoSitePlus
S65 Phosphorylation P27361 (MAPK3) , P42345 (MTOR) , P28482 (MAPK1) , O75582 (RPS6KA5) , Q8TAI7 (RHEBL1) , P31749 (AKT1) , Q92630 (DYRK2) , Q9P1W9 (PIM2) , P06493 (CDK1) , Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11777913, 28272965, 27056897, ...11553333, 20880835, 10942774, 24205284, 12869584, 33038921, 27402756, 12912989, 22578813, 29750193, 32188029, 24931163, 29233971, 11691836, 26832959, 19651622, 30931929, 23186163, 33191406, 16825247, 12860993, 22421144, 29795412, 19487463, 12588975, 22808163, 30602778, 20068231, 24275569, 24923301, 16123140, 24970798, 20616057, 23814053, 29507660, 31284427, 23082216, 33130472, 22657251, 18767875, 31201269, 24466059, 25486193, 29357370, 33658483, 27055259, 28915586, 22267338, 24316235, 25999352, 8083223, 31122207, 28903425, 25702871, 19331694, 24562770, 17287340, 17081983, 27387559, 25880415, 25961827, 20170512, 12105188, 19664995, 31138781, 27065332, 11278829, 31073371, 18669648, 26434594, 12054859, 32603377, 32075852, 12747827
T68 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
K69 Ubiquitination PhosphoSitePlus
T70 Phosphorylation P28482 (MAPK1) , P06493 (CDK1) , Q16539 (MAPK14) , P42345 (MTOR) , P41279 (MAP3K8) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11777913, 20142804, 29750193, ...11553333, 10942774, 21132000, 33038921, 27402756, 28272965, 28213783, 25762619, 32188029, 29233971, 32981220, 11691836, 26832959, 28475412, 30931929, 21406692, 23186163, 33191406, 16825247, 12860993, 22421144, 29795412, 19487463, 22808163, 23340172, 12370290, 30602778, 24275569, 12747827, 24970798, 27065332, 12912989, 11410517, 18220336, 31201269, 25486193, 28915586, 19804365, 24605337, 31122207, 30397197, 19651622, 19331694, 17287340, 17081983, 27387559, 29845289, 25961827, 25702871, 19664995, 18669648, 20068231, 12054859, 32603377, 22578813, 24358826, 32075852
T77 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18669648, 24275569
T82 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S83 Phosphorylation P42345 (MTOR) , P06493 (CDK1) , P28482 (MAPK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10779345, 9204908, 31201269, ...9405468, 30931929, 27402756, 18669648, 9092573, 11691836
S85 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S86 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17081983
S94 Phosphorylation Q13315 (ATM) , Q13535 (ATR) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus 10608806, 17287340, 17081983, ...18669648, 20068231
S96 Phosphorylation HPRD 17081983
S101 Phosphorylation Q92630 (DYRK2) , P42345 (MTOR) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18220336, 31201269, ...12588975, 19651622, 32188029, 17287340, 24358826, 12912989, 20068231
S112 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) , Q13315 (ATM) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11146653, 17525332, 23186163, ...18212344, 21406692, 12588975, 9806882
Site PTM Type PTM Enzyme Score Source PMID
T37 Phosphorylation PRO
T46 Phosphorylation PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044854 (hEIF4EBP1/InitMet-/AcPhos:1) pS94 PRO
PR:000044855 (hEIF4EBP1/InitMet-/AcPhos:2) pS94,pS101 PRO
PR:000026216 (hEIF4EBP1/iso:1/Phos:1) pT37,pT46 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13541 (EIF4EBP1) S65 P06730 (EIF4E) increased_association eFIP 31138781
Phosphorylation Q13541 (EIF4EBP1) T36 P06730 (EIF4E) inhibited_association eFIP 10405182
Phosphorylation Q13541 (EIF4EBP1) T70 P06730 (EIF4E) inhibited_association eFIP 31201269
Phosphorylation Q13541 (EIF4EBP1) T70 P06730 (EIF4E) inhibited_association eFIP 12054859
Phosphorylation Q13541 (EIF4EBP1) T37 P06730 (EIF4E) inhibited_association eFIP 24358826


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S35 I35 Biomuta DOID:3571 / liver cancer [ icgc ]
T41 S41 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y54 N54 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R63 W63 Biomuta DOID:1909 / melanoma [ cosmic ]
S86 N86 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S94 I94 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S101 C101 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]