iPTMnet Report Q13492 PICALM

Protein Information

UniProt AC / UniProt ID	Q13492 / PICAL_HUMAN
Protein Name	Phosphatidylinositol-binding clathrin assembly protein
Gene Name	Name: PICALM Synonyms:CALM;
Organism	Homo sapiens (Human)

PRO ID	PR:Q13492 DAG View
PRO Name	phosphatidylinositol-binding clathrin assembly protein (human)
Definition	A phosphatidylinositol-binding clathrin assembly protein that is encoded in the genome of human.
Short Label	hPICALM
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q13492 (PICALM) as Substrate

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S2 S5 R9 T11 S16 T18 S20 S23 K24 K28 T82 Y88 S107 K112 K134 Y138 T146 K163 K231 Y237 K238 S248 K252 K288 K291 S293 T294 S297 T301 S303 S307 S308 T312 S315 K318 K324 K336 T352 S353 T355 T356 S359 T363 S364 T370 T379 S381 S382 S383 S385 S409 S443 S450 S452 S453 S474 S497 T498 K515 T517 S537 S543 K559 S565 K570 K571 T573 S576 T585 T586 R636 S645	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	Score Select all 1 2	Source Select all GlyGen IEDB PhosphoSitePlus UniProt phospho.ELM	PMID
S2	Acetylation	score1	UniProt	19413330, 21406692, 22814378
S2	Phosphorylation	score1	PhosphoSitePlus
S5	Phosphorylation	score1	PhosphoSitePlus
R9	Methylation	score1	PhosphoSitePlus
T11	Phosphorylation	score1	PhosphoSitePlus
S16	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163, 24275569
T18	Phosphorylation	score1	PhosphoSitePlus
S20	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S23	Phosphorylation	score1	PhosphoSitePlus
K24	Ubiquitination	score1	PhosphoSitePlus
K28	Acetylation	score1	PhosphoSitePlus
T82	Phosphorylation	score1	PhosphoSitePlus
Y88	Phosphorylation	score1	PhosphoSitePlus
S107	Phosphorylation	score1	PhosphoSitePlus
K112	Ubiquitination	score1	PhosphoSitePlus
K134	Ubiquitination	score1	PhosphoSitePlus
Y138	Phosphorylation	score1	PhosphoSitePlus
T146	Phosphorylation	score1	PhosphoSitePlus
K163	Ubiquitination	score1	PhosphoSitePlus
K231	Ubiquitination	score1	PhosphoSitePlus
Y237	Phosphorylation	score1	PhosphoSitePlus
K238	Sumoylation	score1	PhosphoSitePlus
S248	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
K252	Ubiquitination	score1	PhosphoSitePlus
K288	Ubiquitination	score1	PhosphoSitePlus
K291	Ubiquitination	score1	PhosphoSitePlus
S293	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T294	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S297	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S297	Phosphorylation	score1	PhosphoSitePlus
T301	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
S303	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S307	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
S308	Phosphorylation	score1	PhosphoSitePlus
T312	Phosphorylation	score1	PhosphoSitePlus
S315	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
K318	Ubiquitination	score1	PhosphoSitePlus
K324	Ubiquitination	score1	PhosphoSitePlus
K336	Ubiquitination	score1	PhosphoSitePlus
T352	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S353	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T355	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T356	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T356	Phosphorylation	score1	PhosphoSitePlus
S359	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S359	Phosphorylation	score1	PhosphoSitePlus
T363	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 32938750, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T363	Phosphorylation	score1	PhosphoSitePlus
S364	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 32938750, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T370	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T379	Phosphorylation	score1	PhosphoSitePlus
S381	Phosphorylation	score1	PhosphoSitePlus
S382	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S383	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S385	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S409	O-Glycosylation	score2	GlyGen IEDB	28314751
S443	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S450	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S450	Phosphorylation	score1	PhosphoSitePlus
S452	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S453	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S474	Phosphorylation	score1	PhosphoSitePlus
S497	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T498	O-Glycosylation	score1	GlyGen	33465208
K515	Ubiquitination	score1	PhosphoSitePlus
T517	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
S537	Phosphorylation	score1	PhosphoSitePlus
S543	Phosphorylation	score1	PhosphoSitePlus
K559	Ubiquitination	score1	PhosphoSitePlus
S565	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
K570	Ubiquitination	score1	PhosphoSitePlus
K571	Ubiquitination	score1	PhosphoSitePlus
T573	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T573	Phosphorylation	score1	PhosphoSitePlus
S576	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T585	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
T586	O-Glycosylation	score1	GlyGen	30444036, 28314751, 35138101, ...30620550, 31492838, 29351928, 22661428, 29237092, 27114449, 34725712, 33465208, 32119511, 30397120, 35132862, 29485866, 28657654, 27655845, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 28510447, 34229054
R636	Methylation	score1	PhosphoSitePlus
S645	Phosphorylation	score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine By position S107 T301 S303 S307 S308 S359 T363 T379 T462 S474	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
S107	Phosphorylation	score0	HPRD	20068231
T301	Phosphorylation	score0	HPRD	18669648
S303	Phosphorylation	score0	HPRD	18669648
S307	Phosphorylation	score0	HPRD	18669648, 20068231
S308	Phosphorylation	score0	HPRD	18452278
S359	Phosphorylation	score0	HPRD	20068231
T363	Phosphorylation	score0	HPRD	20068231
T379	Phosphorylation	score0	HPRD	20068231
T462	Phosphorylation	score0	HPRD	20068231
S474	Phosphorylation	score0	HPRD	20068231

Search:

Site Select all By amino acid All Serine All Threonine By position S107 T301 S303 S307 S308 S359 T363 T379	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
S107	Phosphorylation	score0	HPRD	20068231
T301	Phosphorylation	score0	HPRD	18669648
S303	Phosphorylation	score0	HPRD	18669648
S307	Phosphorylation	score0	HPRD	18669648, 20068231
S308	Phosphorylation	score0	HPRD	18452278
S359	Phosphorylation	score0	HPRD	20068231
T363	Phosphorylation	score0	HPRD	20068231
T379	Phosphorylation	score0	HPRD	20068231

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position T18 S20 K24 K112 K252 K288 S297 K318 S385 S443 S453 T462 S497 S537 T573 S576 R636 S645	Variant Select all * C20 F20 F497 K462 L453 N18 N252 N288 N297 N443 N573 P645 Q24 R112 S636 T318 T385 Y537 Y576	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T18	N18	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S20	C20	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S20	F20	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
K24	Q24	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K112	R112	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K252	N252	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
K288	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K288	N288	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S297	N297	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K318	T318	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S385	T385	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S443	N443	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S453	L453	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S453	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T462	K462	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S497	F497	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S537	Y537	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
T573	N573	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S576	Y576	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
R636	S636	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S645	P645	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q13492 (PICALM)

Protein Information

Interactive Sequence View

Q13492 (PICALM) as Substrate

PTM sites affected in variants