Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13492 / PICAL_HUMAN
Protein Name Phosphatidylinositol-binding clathrin assembly protein
Gene Name Name: PICALM
Synonyms:CALM;
Organism Homo sapiens (Human)

PRO ID PR:Q13492
DAG View
PRO Name phosphatidylinositol-binding clathrin assembly protein (human)
Definition A phosphatidylinositol-binding clathrin assembly protein that is encoded in the genome of human.
Short Label hPICALM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13492 (PICALM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692, 22814378
S2 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
R9 Methylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T18 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus   UniProt 23186163
S23 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
K238 Sumoylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S293 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
T294 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
S297 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
S297 Phosphorylation PhosphoSitePlus
T301 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S307 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S308 Phosphorylation PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus   UniProt 23186163
K318 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
T352 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
S353 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
T355 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
T356 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
T356 Phosphorylation PhosphoSitePlus
S359 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
S359 Phosphorylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S443 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
S450 Phosphorylation PhosphoSitePlus
S453 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
S474 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
T517 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
S537 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
S565 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
K570 Ubiquitination PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
T573 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
T573 Phosphorylation PhosphoSitePlus
S576 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
T585 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
T586 O-Glycosylation GlyGen 27655845, 27114449, 28314751, ...30397120, 30444036, 29351928, 22661428, 29485866, 32119511, 28510447, 28657654, 29237092, 30059200
R636 Methylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S107 Phosphorylation HPRD 20068231
T301 Phosphorylation HPRD 18669648
S303 Phosphorylation HPRD 18669648
S307 Phosphorylation HPRD 18669648, 20068231
S308 Phosphorylation HPRD 18452278
S359 Phosphorylation HPRD 20068231
T363 Phosphorylation HPRD 20068231
T379 Phosphorylation HPRD 20068231
T462 Phosphorylation HPRD 20068231
S474 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S107 Phosphorylation HPRD 20068231
T301 Phosphorylation HPRD 18669648
S303 Phosphorylation HPRD 18669648
S307 Phosphorylation HPRD 18669648, 20068231
S308 Phosphorylation HPRD 18452278
S359 Phosphorylation HPRD 20068231
T363 Phosphorylation HPRD 20068231
T379 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 C20 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S20 F20 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K24 Q24 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K112 R112 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K252 N252 Biomuta DOID:3571 / liver cancer [ tcga ]
K288 * Biomuta DOID:1324 / lung cancer [ icgc ]
K288 N288 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K318 T318 Biomuta DOID:363 / uterine cancer [ tcga ]
S453 L453 Biomuta DOID:1324 / lung cancer [ tcga ]
S453 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T462 K462 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S474 Y474 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S537 Y537 Biomuta DOID:10534 / stomach cancer [ tcga ]
T573 N573 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S576 Y576 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R636 S636 Biomuta DOID:3571 / liver cancer [ icgc ]