Protein Information

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UniProt AC / UniProt ID Q13480 / GAB1_HUMAN
Protein Name GRB2-associated-binding protein 1
Gene Name Name: GAB1
Organism Homo sapiens (Human)

PRO ID PR:Q13480
DAG View
PRO Name GRB2-associated-binding protein 1 (human)
Definition A GRB2-associated-binding protein 1 that is encoded in the genome of human.
Short Label hGAB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13480 (GAB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
Y47 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
C213 S-Nitrosylation dbSNO 26338901
K221 Ubiquitination PhosphoSitePlus
Y242 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10978177, 19881549
Y242 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 10978177
Y242 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19881549
S244 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 23186163
S253 Phosphorylation PhosphoSitePlus   UniProt 23186163
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
Y259 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12522270, 19881549
Y259 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19881549
Y265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12522270, 23186163
S274 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10978177, 10734310, 9890893
Y285 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y285 Phosphorylation P06213 (INSR) PhosphoSitePlus 10978177
Y285 Phosphorylation P08581 (MET) neXtProt   phospho.ELM   Signor 10734310
S304 Phosphorylation PhosphoSitePlus   UniProt 23186163
S306 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 19350053, 16849525, 24662916, ...26246598, 10734310, 25971889
Y307 Phosphorylation P00533 (EGFR) phospho.ELM 10734310
Y307 Phosphorylation P08581 (MET) neXtProt   phospho.ELM 10734310
T312 Phosphorylation neXtProt   PhosphoSitePlus 15379552
T312 Phosphorylation P28482 (MAPK1) neXtProt 15379552
T316 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15231819, 15574420, 19881549, ...16497976
Y317 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19881549
T322 O-Glycosylation GlyGen 23301498, 28580691, 28657654, ...30379171
S355 Phosphorylation PhosphoSitePlus
T365 O-Glycosylation GlyGen 23301498, 28580691, 28657654, ...30379171
T365 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
Y373 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10753869, 19881549, 10978177, ...9890893, 10734310
Y373 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y373 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 10978177
Y373 Phosphorylation P08581 (MET) neXtProt   phospho.ELM 10734310
Y373 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19881549
S381 Phosphorylation neXtProt   PhosphoSitePlus 15379552
S381 Phosphorylation P28482 (MAPK1) neXtProt 15379552
S383 Phosphorylation PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22751113, 23186163
S389 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y406 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18083107, 9890893, 10734310, ...10753869
Y406 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y406 Phosphorylation P08581 (MET) neXtProt   phospho.ELM 10734310
S417 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
Y447 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10978177, 26246598, 9658397, ...9890893, 10734310
Y447 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y447 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 10978177, 9658397
Y447 Phosphorylation P08581 (MET) neXtProt   phospho.ELM 10734310
S454 Phosphorylation neXtProt   PhosphoSitePlus 15379552
S454 Phosphorylation P28482 (MAPK1) neXtProt 15379552
Y472 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10978177, 26246598, 9658397, ...9890893, 10734310
Y472 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y472 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 10978177, 9658397
Y472 Phosphorylation P08581 (MET) neXtProt   phospho.ELM 10734310
T476 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 15379552
T476 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus 15379552
S500 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
A547 Phosphorylation UniProt 18669648
S551 Phosphorylation PhosphoSitePlus   RLIMS-P 19050043
S582 Phosphorylation neXtProt 15379552
S582 Phosphorylation P28482 (MAPK1) neXtProt 15379552
Y589 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10978177, 20308328, 24935154, ...26246598, 9658397, 9890893, 10734310
Y589 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y589 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 10978177, 9658397
Y589 Phosphorylation P08581 (MET) neXtProt   phospho.ELM   Signor 10734310
S597 Phosphorylation neXtProt 15379552
S597 Phosphorylation P28482 (MAPK1) neXtProt 15379552
Y627 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 34929201, 11323411, 25569504, ...19881549, 15231819, 10978177, 9890893, 14973141, 11453982, 22777356, 18083107, 26246598, 10734310, 9658397, 24662916, 27530552, 12855672, 31651330, 20068231, 28365441
Y627 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y627 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 10978177, 9658397
Y627 Phosphorylation P08581 (MET) neXtProt   phospho.ELM   Signor 10734310
Y627 Phosphorylation P09619 (PDGFRB) neXtProt 14973141
Y627 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19881549
S634 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
T638 Phosphorylation PhosphoSitePlus   UniProt 23186163
S645 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y659 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10978177, 11323411, 23186163, ...14973141, 34929201, 18669648, 18083107, 9890893, 10734310, 12855672
Y659 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor 9890893
Y659 Phosphorylation P06213 (INSR) PhosphoSitePlus 10978177
Y659 Phosphorylation P08581 (MET) neXtProt   phospho.ELM   Signor 10734310
Y659 Phosphorylation P09619 (PDGFRB) neXtProt 14973141
T673 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus   UniProt 23186163
T684 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y242 Phosphorylation HPRD 10978177, 16497976
Y242 Phosphorylation P06213 (INSR) HPRD 10978177, 16497976
Y259 Phosphorylation HPRD 17016520, 12522270, 19901323, ...16497976
S266 Phosphorylation HPRD 12522270
Y285 Phosphorylation HPRD 10978177, 10734310
Y285 Phosphorylation P00533 (EGFR) HPRD 10734310
Y285 Phosphorylation P06213 (INSR) HPRD 10978177
Y285 Phosphorylation P08581 (MET) HPRD 10734310
Y307 Phosphorylation HPRD 10734310, 16497976
Y307 Phosphorylation P00533 (EGFR) HPRD 10734310, 16497976
Y307 Phosphorylation P08581 (MET) HPRD 10734310, 16497976
T312 Phosphorylation HPRD 15379552
T312 Phosphorylation P27361 (MAPK3) HPRD 15379552
T312 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y317 Phosphorylation HPRD 16497976
S355 Phosphorylation HPRD 19664994
Y373 Phosphorylation HPRD 10978177, 17389395, 16497976
Y373 Phosphorylation P00533 (EGFR) HPRD 10978177, 17389395, 16497976
Y373 Phosphorylation P06213 (INSR) HPRD 10978177, 17389395, 16497976
Y373 Phosphorylation P08581 (MET) HPRD 10978177, 17389395, 16497976
S381 Phosphorylation HPRD 15379552
S381 Phosphorylation P27361 (MAPK3) HPRD 15379552
S381 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y406 Phosphorylation HPRD 17016520, 10734310, 17389395, ...19901323, 16497976
Y406 Phosphorylation P00533 (EGFR) HPRD 17016520, 10734310, 17389395, ...19901323, 16497976
Y406 Phosphorylation P08581 (MET) HPRD 17016520, 10734310, 17389395, ...19901323, 16497976
Y447 Phosphorylation HPRD 10978177, 10734310
Y447 Phosphorylation P00533 (EGFR) HPRD 10734310
Y447 Phosphorylation P06213 (INSR) HPRD 10978177
Y447 Phosphorylation P08581 (MET) HPRD 10734310
S454 Phosphorylation HPRD 15379552
S454 Phosphorylation P27361 (MAPK3) HPRD 15379552
S454 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y472 Phosphorylation HPRD 10978177, 10734310
Y472 Phosphorylation P00533 (EGFR) HPRD 10734310
Y472 Phosphorylation P06213 (INSR) HPRD 10978177
Y472 Phosphorylation P08581 (MET) HPRD 10734310
T476 Phosphorylation HPRD 15379552
T476 Phosphorylation P27361 (MAPK3) HPRD 15379552
T476 Phosphorylation P28482 (MAPK1) HPRD 15379552
S551 Phosphorylation HPRD 15379552
S551 Phosphorylation P27361 (MAPK3) HPRD 15379552
S551 Phosphorylation P28482 (MAPK1) HPRD 15379552
S567 Phosphorylation HPRD 15379552
S567 Phosphorylation P27361 (MAPK3) HPRD 15379552
S567 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y589 Phosphorylation HPRD 10978177, 10734310
Y589 Phosphorylation P00533 (EGFR) HPRD 10734310
Y589 Phosphorylation P06213 (INSR) HPRD 10978177
Y589 Phosphorylation P08581 (MET) HPRD 10734310
Y627 Phosphorylation HPRD 17016520, 10734310, 17389395, ...20068231
Y627 Phosphorylation P00533 (EGFR) HPRD 17016520, 10734310, 17389395, ...20068231
Y627 Phosphorylation P06213 (INSR) HPRD 17016520, 10734310, 17389395, ...20068231
Y627 Phosphorylation P08581 (MET) HPRD 17016520, 10734310, 17389395, ...20068231
S634 Phosphorylation HPRD 20068231
S637 Phosphorylation HPRD 20068231
Y659 Phosphorylation HPRD 10734310, 18669648, 17389395, ...16497976
Y659 Phosphorylation P00533 (EGFR) HPRD 10734310, 18669648, 17389395, ...16497976
Y659 Phosphorylation P06213 (INSR) HPRD 10734310, 18669648, 17389395, ...16497976
Y659 Phosphorylation P08581 (MET) HPRD 10734310, 18669648, 17389395, ...16497976
Site PTM Type PTM Enzyme Score Source PMID
Y242 Phosphorylation HPRD   PhosphoSitePlus 10978177, 16497976
Y242 Phosphorylation P06213 (INSR) HPRD 10978177, 16497976
Y259 Phosphorylation HPRD   PhosphoSitePlus 17016520, 16497976, 19901323, ...12522270
S266 Phosphorylation HPRD 12522270
Y285 Phosphorylation HPRD   neXtProt 10978177, 10734310, 9890893
Y285 Phosphorylation P00533 (EGFR) HPRD   neXtProt 10734310, 9890893
Y285 Phosphorylation P06213 (INSR) HPRD 10978177
Y285 Phosphorylation P08581 (MET) HPRD 10734310
Y307 Phosphorylation HPRD 10734310, 16497976
Y307 Phosphorylation P00533 (EGFR) HPRD 10734310, 16497976
Y307 Phosphorylation P08581 (MET) HPRD 10734310, 16497976
T312 Phosphorylation HPRD 15379552
T312 Phosphorylation P27361 (MAPK3) HPRD 15379552
T312 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y317 Phosphorylation HPRD   PhosphoSitePlus 16497976
S355 Phosphorylation HPRD 19664994
Y373 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 10978177, 17389395, 9890893, ...16497976
Y373 Phosphorylation P00533 (EGFR) neXtProt 9890893
Y373 Phosphorylation P06213 (INSR) HPRD 10978177, 17389395, 16497976
Y373 Phosphorylation P08581 (MET) HPRD 10978177, 17389395, 16497976
S381 Phosphorylation HPRD 15379552
S381 Phosphorylation P27361 (MAPK3) HPRD 15379552
S381 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y406 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 17016520, 17389395, 19901323, ...9890893, 10734310, 16497976
Y406 Phosphorylation P00533 (EGFR) HPRD   neXtProt 17016520, 19901323, 17389395, ...9890893, 10734310, 16497976
Y406 Phosphorylation P08581 (MET) HPRD 17016520, 10734310, 17389395, ...19901323, 16497976
Y447 Phosphorylation HPRD   neXtProt 10978177, 10734310, 9890893
Y447 Phosphorylation P00533 (EGFR) HPRD   neXtProt 10734310, 9890893
Y447 Phosphorylation P06213 (INSR) HPRD 10978177
Y447 Phosphorylation P08581 (MET) HPRD 10734310
S454 Phosphorylation HPRD 15379552
S454 Phosphorylation P27361 (MAPK3) HPRD 15379552
S454 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y472 Phosphorylation HPRD   neXtProt 10978177, 10734310, 9890893
Y472 Phosphorylation P00533 (EGFR) HPRD   neXtProt 10734310, 9890893
Y472 Phosphorylation P06213 (INSR) HPRD 10978177
Y472 Phosphorylation P08581 (MET) HPRD 10734310
T476 Phosphorylation HPRD 15379552
T476 Phosphorylation P27361 (MAPK3) HPRD 15379552
T476 Phosphorylation P28482 (MAPK1) HPRD 15379552
S547 Phosphorylation HPRD   PhosphoSitePlus 18669648
T549 Phosphorylation PhosphoSitePlus
S581 Phosphorylation HPRD 15379552
S581 Phosphorylation P27361 (MAPK3) HPRD 15379552
S581 Phosphorylation P28482 (MAPK1) HPRD 15379552
S597 Phosphorylation HPRD 15379552
S597 Phosphorylation P27361 (MAPK3) HPRD 15379552
S597 Phosphorylation P28482 (MAPK1) HPRD 15379552
Y619 Phosphorylation HPRD   neXtProt 10978177, 10734310, 9890893
Y619 Phosphorylation P00533 (EGFR) HPRD   neXtProt 10734310, 9890893
Y619 Phosphorylation P06213 (INSR) HPRD 10978177
Y619 Phosphorylation P08581 (MET) HPRD 10734310
Y657 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 17016520, 17389395, 9890893, ...10734310, 20068231
Y657 Phosphorylation P00533 (EGFR) HPRD   neXtProt 17016520, 10734310, 17389395, ...20068231, 9890893
Y657 Phosphorylation P06213 (INSR) HPRD 17016520, 10734310, 17389395, ...20068231
Y657 Phosphorylation P08581 (MET) HPRD 17016520, 10734310, 17389395, ...20068231
S664 Phosphorylation HPRD 20068231
S667 Phosphorylation HPRD 20068231
Y689 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 17389395, 18669648, 9890893, ...10734310, 16497976
Y689 Phosphorylation P00533 (EGFR) HPRD   neXtProt 16497976, 10734310, 18669648, ...17389395, 9890893
Y689 Phosphorylation P06213 (INSR) HPRD 10734310, 18669648, 17389395, ...16497976
Y689 Phosphorylation P08581 (MET) HPRD 10734310, 18669648, 17389395, ...16497976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047484 (hGAB1/Phos:1) pY447,pY472,pY589,pY627,pY659 PRO
PR:000047485 (hGAB1/Phos:2) pY627,pY659 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P08581 (MET) Y1349 Q13480 (GAB1) increased_association eFIP 18046719