Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13480 / GAB1_HUMAN
Protein Name GRB2-associated-binding protein 1
Gene Name Name: GAB1
Organism Homo sapiens (Human)

PRO ID PR:Q13480
DAG View
PRO Name GRB2-associated-binding protein 1 (human)
Definition A GRB2-associated-binding protein 1 that is encoded in the genome of human.
Short Label hGAB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13480 (GAB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
Y47 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
C213 S-Nitrosylation dbSNO 26338901
K221 Ubiquitination PhosphoSitePlus
Y242 Phosphorylation P12931 (SRC) , P06213 (INSR) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10978177, 19881549
S244 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 23186163
S253 Phosphorylation PhosphoSitePlus   UniProt 23186163
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
Y259 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12522270, 19881549
Y265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12522270, 23186163
S274 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation P00533 (EGFR) , P06213 (INSR) , P08581 (MET) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10978177, 10734310, 9890893
S304 Phosphorylation PhosphoSitePlus   UniProt 23186163
S306 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation P00533 (EGFR) , P08581 (MET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 19350053, 16849525, 24662916, ...26246598, 10734310, 25971889
T312 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 15379552
T316 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15231819, 19881549, 16497976
S355 Phosphorylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
Y373 Phosphorylation P08581 (MET) , P06213 (INSR) , P00533 (EGFR) , P12931 (SRC) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10753869, 19881549, 10978177, ...9890893, 10734310
S381 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 15379552
S383 Phosphorylation PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22751113, 23186163
S389 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y406 Phosphorylation P00533 (EGFR) , P08581 (MET) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18083107, 10753869, 10734310, ...9890893
S417 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
Y447 Phosphorylation P06213 (INSR) , P08581 (MET) , P00533 (EGFR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10978177, 26246598, 9658397, ...9890893, 10734310
S454 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 15379552
Y472 Phosphorylation P00533 (EGFR) , P06213 (INSR) , P08581 (MET) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10978177, 26246598, 9658397, ...9890893, 10734310
T476 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus 15379552
S500 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus   RLIMS-P 19050043
S582 Phosphorylation P28482 (MAPK1) neXtProt 15379552
Y589 Phosphorylation P06213 (INSR) , P00533 (EGFR) , P08581 (MET) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10978177, 26246598, 9658397, ...9890893, 10734310
S597 Phosphorylation P28482 (MAPK1) neXtProt 15379552
Y627 Phosphorylation P06213 (INSR) , P12931 (SRC) , P08581 (MET) , P09619 (PDGFRB) , P00533 (EGFR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18083107, 15231819, 25569504, ...19881549, 10978177, 9890893, 14973141, 24662916, 26246598, 9658397, 10734310, 27530552, 22777356, 20068231, 28365441
S634 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
T638 Phosphorylation PhosphoSitePlus   UniProt 23186163
S645 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y659 Phosphorylation P08581 (MET) , P06213 (INSR) , P00533 (EGFR) , P09619 (PDGFRB) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 10978177, 23186163, 14973141, ...18083107, 18669648, 9890893, 10734310
T673 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus   UniProt 23186163
T684 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y242 Phosphorylation P06213 (INSR) HPRD 10978177, 16497976
Y259 Phosphorylation HPRD 17016520, 12522270, 19901323, ...16497976
S266 Phosphorylation HPRD 12522270
Y285 Phosphorylation P06213 (INSR) , P00533 (EGFR) , P08581 (MET) HPRD 10978177, 10734310
Y307 Phosphorylation P08581 (MET) , P00533 (EGFR) HPRD 10734310, 16497976
T312 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD 15379552
Y317 Phosphorylation HPRD 16497976
S355 Phosphorylation HPRD 19664994
Y373 Phosphorylation P08581 (MET) , P06213 (INSR) , P00533 (EGFR) HPRD 10978177, 17389395, 16497976
S381 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
Y406 Phosphorylation P08581 (MET) , P00533 (EGFR) HPRD 17016520, 10734310, 17389395, ...19901323, 16497976
Y447 Phosphorylation P00533 (EGFR) , P08581 (MET) , P06213 (INSR) HPRD 10978177, 10734310
S454 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
Y472 Phosphorylation P06213 (INSR) , P08581 (MET) , P00533 (EGFR) HPRD 10978177, 10734310
T476 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
S551 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
S567 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
Y589 Phosphorylation P00533 (EGFR) , P06213 (INSR) , P08581 (MET) HPRD 10978177, 10734310
Y627 Phosphorylation P06213 (INSR) , P00533 (EGFR) , P08581 (MET) HPRD 17016520, 10734310, 17389395, ...20068231
S634 Phosphorylation HPRD 20068231
S637 Phosphorylation HPRD 20068231
Y659 Phosphorylation P06213 (INSR) , P08581 (MET) , P00533 (EGFR) HPRD 10734310, 18669648, 17389395, ...16497976
Site PTM Type PTM Enzyme Score Source PMID
Y242 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 10978177, 16497976
Y259 Phosphorylation HPRD   PhosphoSitePlus 17016520, 12522270, 19901323, ...16497976
S266 Phosphorylation HPRD 12522270
Y285 Phosphorylation P06213 (INSR) , P08581 (MET) , P00533 (EGFR) HPRD   neXtProt 10978177, 10734310, 9890893
Y307 Phosphorylation P08581 (MET) , P00533 (EGFR) HPRD 10734310, 16497976
T312 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
Y317 Phosphorylation HPRD   PhosphoSitePlus 16497976
S355 Phosphorylation HPRD 19664994
Y373 Phosphorylation P00533 (EGFR) , P08581 (MET) , P06213 (INSR) HPRD   neXtProt   PhosphoSitePlus 10978177, 16497976, 17389395, ...9890893
S381 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD 15379552
Y406 Phosphorylation P00533 (EGFR) , P08581 (MET) HPRD   neXtProt   PhosphoSitePlus 17016520, 17389395, 19901323, ...9890893, 10734310, 16497976
Y447 Phosphorylation P08581 (MET) , P06213 (INSR) , P00533 (EGFR) HPRD   neXtProt 10978177, 10734310, 9890893
S454 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD 15379552
Y472 Phosphorylation P08581 (MET) , P00533 (EGFR) , P06213 (INSR) HPRD   neXtProt 10978177, 10734310, 9890893
T476 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
S547 Phosphorylation HPRD   PhosphoSitePlus 18669648
S581 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
S597 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 15379552
Y619 Phosphorylation P06213 (INSR) , P00533 (EGFR) , P08581 (MET) HPRD   neXtProt 10978177, 10734310, 9890893
Y657 Phosphorylation P00533 (EGFR) , P08581 (MET) , P06213 (INSR) HPRD   neXtProt   PhosphoSitePlus 17016520, 17389395, 9890893, ...10734310, 20068231
S664 Phosphorylation HPRD 20068231
S667 Phosphorylation HPRD 20068231
Y689 Phosphorylation P06213 (INSR) , P00533 (EGFR) , P08581 (MET) HPRD   neXtProt   PhosphoSitePlus 17389395, 18669648, 9890893, ...10734310, 16497976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047484 (hGAB1/Phos:1) pY447,pY472,pY589,pY627,pY659 PRO
PR:000047485 (hGAB1/Phos:2) pY627,pY659 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P08581 (MET) Y1349 Q13480 (GAB1) increased_association eFIP 18046719


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y48 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y83 C83 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y83 H83 Biomuta DOID:363 / uterine cancer [ tcga ]
T316 A316 Biomuta DOID:1909 / melanoma [ cosmic ]
Y317 C317 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S367 L367 Biomuta DOID:1612 / breast cancer [ tcga ]
T387 N387 Biomuta DOID:1612 / breast cancer [ cosmic ]
S418 I418 Biomuta DOID:3571 / liver cancer [ icgc ]
S645 I645 Biomuta DOID:3571 / liver cancer [ icgc ]