iPTMnet Report for Q13480 (GAB1)
Protein Information
UniProt AC / UniProt ID | Q13480 / GAB1_HUMAN |
Protein Name | GRB2-associated-binding protein 1 |
Gene Name | Name: GAB1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q13480 |
PRO Name | GRB2-associated-binding protein 1 (human) |
Definition | A GRB2-associated-binding protein 1 that is encoded in the genome of human. |
Short Label | hGAB1 |
Category | organism-gene |
Q13480 (GAB1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Acetylation | score1 | UniProt | 22223895 | ||
Y47 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y48 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y83 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y183 | Phosphorylation | score1 | PhosphoSitePlus | |||
K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
C213 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y242 | Phosphorylation | P12931 (SRC) , P06213 (INSR) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 10978177, 19881549 | |
S244 | Phosphorylation | score1 | PhosphoSitePlus | |||
S251 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S253 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S256 | Phosphorylation | score1 | PhosphoSitePlus | |||
S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y259 | Phosphorylation | P12931 (SRC) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 12522270, 19881549 | |
Y265 | Phosphorylation | score1 | PhosphoSitePlus | |||
S266 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 12522270, 23186163 | ||
S274 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y285 | Phosphorylation | P00533 (EGFR) , P06213 (INSR) , P08581 (MET) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 10978177, 10734310, 9890893 | |
S304 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S306 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y307 | Phosphorylation | P00533 (EGFR) , P08581 (MET) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P | 19350053, 16849525, 24662916, ... | |
T312 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 15379552 | |
T316 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y317 | Phosphorylation | P12931 (SRC) | score4 | IntAct phospho.ELM PhosphoSitePlus RLIMS-P Signor | 15231819, 15574420, 19881549, ... | |
T322 | O-Glycosylation | score3 | GlyGen | 23301498, 28580691, 28657654 | ||
S355 | Phosphorylation | score1 | PhosphoSitePlus | |||
T365 | O-Glycosylation | score3 | GlyGen | 23301498, 28580691, 28657654 | ||
T365 | Phosphorylation | score1 | PhosphoSitePlus | |||
S367 | Phosphorylation | score1 | PhosphoSitePlus | |||
T369 | Phosphorylation | score1 | PhosphoSitePlus | |||
S371 | Phosphorylation | score1 | PhosphoSitePlus | |||
S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y373 | Phosphorylation | P08581 (MET) , P12931 (SRC) , P06213 (INSR) , P00533 (EGFR) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 10753869, 19881549, 10978177, ... | |
S381 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 15379552 | |
S383 | Phosphorylation | score1 | PhosphoSitePlus | |||
T387 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 22751113, 23186163 | ||
S389 | Phosphorylation | score1 | PhosphoSitePlus | |||
S401 | Phosphorylation | score1 | PhosphoSitePlus | |||
S402 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
Y406 | Phosphorylation | P00533 (EGFR) , P08581 (MET) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 18083107, 9890893, 10734310, ... | |
S417 | Phosphorylation | score1 | PhosphoSitePlus | |||
S418 | Phosphorylation | score1 | PhosphoSitePlus | |||
S419 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y447 | Phosphorylation | P06213 (INSR) , P08581 (MET) , P00533 (EGFR) | score4 | IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor | 10978177, 26246598, 9658397, ... | |
S454 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 15379552 | |
Y472 | Phosphorylation | P00533 (EGFR) , P06213 (INSR) , P08581 (MET) | score4 | IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor | 10978177, 26246598, 9658397, ... | |
T476 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt phospho.ELM PhosphoSitePlus | 15379552 | |
S500 | Phosphorylation | score1 | PhosphoSitePlus | |||
T503 | Phosphorylation | score1 | PhosphoSitePlus | |||
S551 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 19050043 | ||
S582 | Phosphorylation | P28482 (MAPK1) | score2 | neXtProt | 15379552 | |
Y589 | Phosphorylation | P06213 (INSR) , P08581 (MET) , P00533 (EGFR) | score4 | IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor | 10978177, 20308328, 24935154, ... | |
S597 | Phosphorylation | P28482 (MAPK1) | score2 | neXtProt | 15379552 | |
Y627 | Phosphorylation | P06213 (INSR) , P12931 (SRC) , P08581 (MET) , P09619 (PDGFRB) , P00533 (EGFR) | score4 | IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 24662916, 11323411, 25569504, ... | |
S634 | Phosphorylation | score1 | PhosphoSitePlus | |||
S637 | Phosphorylation | score1 | PhosphoSitePlus | |||
T638 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S645 | Phosphorylation | score1 | PhosphoSitePlus | |||
S651 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
Y659 | Phosphorylation | P08581 (MET) , P06213 (INSR) , P00533 (EGFR) , P09619 (PDGFRB) | score4 | IntAct neXtProt phospho.ELM PRO PhosphoSitePlus Signor UniProt | 10978177, 11323411, 23186163, ... | |
T673 | Phosphorylation | score1 | PhosphoSitePlus | |||
S683 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T684 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y242 | Phosphorylation | P06213 (INSR) | score2 | HPRD | 10978177, 16497976 | |
Y259 | Phosphorylation | score0 | HPRD | 17016520, 12522270, 19901323, ... | ||
S266 | Phosphorylation | score0 | HPRD | 12522270 | ||
Y285 | Phosphorylation | P06213 (INSR) , P00533 (EGFR) , P08581 (MET) | score2 | HPRD | 10978177, 10734310 | |
Y307 | Phosphorylation | P08581 (MET) , P00533 (EGFR) | score2 | HPRD | 10734310, 16497976 | |
T312 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score1 | HPRD | 15379552 | |
Y317 | Phosphorylation | score0 | HPRD | 16497976 | ||
S355 | Phosphorylation | score0 | HPRD | 19664994 | ||
Y373 | Phosphorylation | P06213 (INSR) , P00533 (EGFR) , P08581 (MET) | score2 | HPRD | 10978177, 17389395, 16497976 | |
S381 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score1 | HPRD | 15379552 | |
Y406 | Phosphorylation | P00533 (EGFR) , P08581 (MET) | score2 | HPRD | 17016520, 10734310, 17389395, ... | |
Y447 | Phosphorylation | P08581 (MET) , P06213 (INSR) , P00533 (EGFR) | score2 | HPRD | 10978177, 10734310 | |
S454 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 15379552 | |
Y472 | Phosphorylation | P06213 (INSR) , P00533 (EGFR) , P08581 (MET) | score2 | HPRD | 10978177, 10734310 | |
T476 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 15379552 | |
S551 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 15379552 | |
S567 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 15379552 | |
Y589 | Phosphorylation | P06213 (INSR) , P08581 (MET) , P00533 (EGFR) | score2 | HPRD | 10978177, 10734310 | |
Y627 | Phosphorylation | P00533 (EGFR) , P06213 (INSR) , P08581 (MET) | score2 | HPRD | 17016520, 10734310, 17389395, ... | |
S634 | Phosphorylation | score0 | HPRD | 20068231 | ||
S637 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y659 | Phosphorylation | P00533 (EGFR) , P08581 (MET) , P06213 (INSR) | score2 | HPRD | 10734310, 18669648, 17389395, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y242 | Phosphorylation | P06213 (INSR) | score4 | HPRD PhosphoSitePlus | 10978177, 16497976 | |
Y259 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17016520, 16497976, 19901323, ... | ||
S266 | Phosphorylation | score0 | HPRD | 12522270 | ||
Y285 | Phosphorylation | P08581 (MET) , P06213 (INSR) , P00533 (EGFR) | score4 | HPRD neXtProt | 10978177, 10734310, 9890893 | |
Y307 | Phosphorylation | P08581 (MET) , P00533 (EGFR) | score2 | HPRD | 10734310, 16497976 | |
T312 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 15379552 | |
Y317 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 16497976 | ||
S355 | Phosphorylation | score0 | HPRD | 19664994 | ||
Y373 | Phosphorylation | P08581 (MET) , P00533 (EGFR) , P06213 (INSR) | score4 | HPRD neXtProt PhosphoSitePlus | 10978177, 17389395, 9890893, ... | |
S381 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score1 | HPRD | 15379552 | |
Y406 | Phosphorylation | P00533 (EGFR) , P08581 (MET) | score4 | HPRD neXtProt PhosphoSitePlus | 17016520, 17389395, 19901323, ... | |
Y447 | Phosphorylation | P08581 (MET) , P00533 (EGFR) , P06213 (INSR) | score4 | HPRD neXtProt | 10978177, 10734310, 9890893 | |
S454 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score1 | HPRD | 15379552 | |
Y472 | Phosphorylation | P08581 (MET) , P00533 (EGFR) , P06213 (INSR) | score4 | HPRD neXtProt | 10978177, 10734310, 9890893 | |
T476 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score1 | HPRD | 15379552 | |
S547 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648 | ||
T549 | Phosphorylation | score1 | PhosphoSitePlus | |||
S581 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 15379552 | |
S597 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 15379552 | |
Y619 | Phosphorylation | P06213 (INSR) , P00533 (EGFR) , P08581 (MET) | score4 | HPRD neXtProt | 10978177, 10734310, 9890893 | |
Y657 | Phosphorylation | P00533 (EGFR) , P08581 (MET) , P06213 (INSR) | score4 | HPRD neXtProt PhosphoSitePlus | 17016520, 17389395, 9890893, ... | |
S664 | Phosphorylation | score0 | HPRD | 20068231 | ||
S667 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y689 | Phosphorylation | P06213 (INSR) , P08581 (MET) , P00533 (EGFR) | score4 | HPRD neXtProt PhosphoSitePlus | 17389395, 18669648, 9890893, ... |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000047484 (hGAB1/Phos:1) | pY447,pY472,pY589,pY627,pY659 | PRO | |||
PR:000047485 (hGAB1/Phos:2) | pY627,pY659 | PRO |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P08581 (MET) | Y1349 | Q13480 (GAB1) | increased_association | eFIP | 18046719 | |
Phosphorylation | Q13480 (GAB1) | Y589 | Q06124 (PTPN11) | unknown | eFIP | 20308328 | |
Phosphorylation | Q13480 (GAB1) | Y659 | Q06124 (PTPN11) | unknown | eFIP | 11323411 | |
Phosphorylation | Q13480 (GAB1) | Y472 | P27986 (PIK3R1) | unknown | eFIP | 10978177 | |
Phosphorylation | Q13480 (GAB1) | Y659 | Q06124 (PTPN11) | unknown | eFIP | 12855672 | |
Phosphorylation | Q13480 (GAB1) | Y317 | P20936 (RASA1) | unknown | eFIP | 15574420 | |
Phosphorylation | Q13480 (GAB1) | Y627 | Q06124 (PTPN11) | unknown | eFIP | 11453982 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y48 | * | Biomuta | DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ] | |
Y83 | C83 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
Y83 | H83 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
T316 | A316 | Biomuta | DOID:1909 / melanoma [ cosmic ] | |
Y317 | C317 | Biomuta | DOID:1324 / lung cancer [ cosmic, tcga ] | |
S367 | L367 | Biomuta | DOID:1612 / breast cancer [ tcga ] | |
T387 | N387 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S418 | I418 | Biomuta | DOID:3571 / liver cancer [ icgc ] | |
S645 | I645 | Biomuta | DOID:3571 / liver cancer [ icgc ] |