iPTMnet Report Q13464 ROCK1

Protein Information

UniProt AC / UniProt ID	Q13464 / ROCK1_HUMAN
Protein Name	Rho-associated protein kinase 1
Gene Name	Name: ROCK1
Organism	Homo sapiens (Human)

PRO ID	PR:Q13464 DAG View
PRO Name	Rho-associated protein kinase 1 (human)
Definition	A Rho-associated protein kinase 1 that is encoded in the genome of human.
Short Label	hROCK1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q13464 (ROCK1) as Substrate

Q13464

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S2	Acetylation		score1	UniProt	22814378
S2	Phosphorylation		score1	PhosphoSitePlus
T3	Phosphorylation		score1	PhosphoSitePlus
K13	Ubiquitination		score1	PhosphoSitePlus
K65	Ubiquitination		score1	PhosphoSitePlus
K80	Ubiquitination		score1	PhosphoSitePlus
K109	Ubiquitination		score1	PhosphoSitePlus
S118	Phosphorylation		score1	PhosphoSitePlus
K200	Ubiquitination		score1	PhosphoSitePlus
K225	Ubiquitination		score1	PhosphoSitePlus
Y255	Phosphorylation		score1	PhosphoSitePlus
S282	Phosphorylation		score1	PhosphoSitePlus
K294	Ubiquitination		score1	PhosphoSitePlus
K307	Ubiquitination		score1	PhosphoSitePlus
K339	Ubiquitination		score1	PhosphoSitePlus
T398	Phosphorylation		score1	PhosphoSitePlus
Y405	Phosphorylation		score1	PhosphoSitePlus
S407	Phosphorylation		score1	PhosphoSitePlus
K430	Ubiquitination		score1	PhosphoSitePlus
T455	Phosphorylation		score2	HPRD PhosphoSitePlus	18767875
S456	Phosphorylation		score2	HPRD PhosphoSitePlus	18767875
S533	Phosphorylation		score1	PhosphoSitePlus
K539	Ubiquitination		score1	PhosphoSitePlus
S567	Phosphorylation		score1	PhosphoSitePlus
T569	Phosphorylation		score1	PhosphoSitePlus
S572	Phosphorylation		score1	PhosphoSitePlus
S574	Phosphorylation		score1	PhosphoSitePlus
S576	Phosphorylation		score1	PhosphoSitePlus
S580	Phosphorylation		score1	PhosphoSitePlus
Y603	Phosphorylation		score1	PhosphoSitePlus
Y604	Phosphorylation		score1	PhosphoSitePlus
K647	Acetylation		score2	PhosphoSitePlus UniProt	19608861
S679	Phosphorylation		score1	PhosphoSitePlus
S710	Phosphorylation		score1	PhosphoSitePlus
K718	Acetylation		score1	PhosphoSitePlus
S742	Phosphorylation		score1	PhosphoSitePlus
K782	Ubiquitination		score1	PhosphoSitePlus
K857	Ubiquitination		score1	PhosphoSitePlus
T887	Phosphorylation		score1	PhosphoSitePlus
T890	Phosphorylation		score1	PhosphoSitePlus
T897	Phosphorylation		score1	PhosphoSitePlus
K898	Ubiquitination		score1	PhosphoSitePlus
Y913	Phosphorylation		score1	PhosphoSitePlus
T917	Phosphorylation		score1	PhosphoSitePlus
K921	Ubiquitination		score1	PhosphoSitePlus
K950	Ubiquitination		score1	PhosphoSitePlus
T1024	Phosphorylation		score3	neXtProt PhosphoSitePlus	21685893
T1024	Phosphorylation	P41743 (PRKCI)	score2	neXtProt	21685893
K1057	Ubiquitination		score1	PhosphoSitePlus
K1093	Ubiquitination		score1	PhosphoSitePlus
S1098	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18669648
S1100	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18669648
T1101	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18669648, 20068231
S1102	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	19651622, 18669648
S1105	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	19651622, 19690332, 20068231, ...18691976
S1108	Phosphorylation		score1	PhosphoSitePlus
T1112	Phosphorylation		score1	PhosphoSitePlus
S1119	Phosphorylation		score1	PhosphoSitePlus
Y1153	Phosphorylation		score1	PhosphoSitePlus
T1180	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	17525332
T1189	Phosphorylation		score1	PhosphoSitePlus
K1194	Acetylation		score1	PhosphoSitePlus
Y1287	Phosphorylation		score1	PhosphoSitePlus
S1301	Phosphorylation		score1	IEDB	32387766
S1322	Phosphorylation		score1	PhosphoSitePlus
S1328	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T1331	Phosphorylation		score1	PhosphoSitePlus
S1333	Phosphorylation		score4	neXtProt PhosphoSitePlus RLIMS-P	24168723, 21685893
S1333	Phosphorylation	P41743 (PRKCI)	score2	neXtProt	21685893
T1334	Phosphorylation		score3	neXtProt PhosphoSitePlus	21685893
T1334	Phosphorylation	P41743 (PRKCI)	score2	neXtProt	21685893
S1336	O-Glycosylation		score1	GlyGen	35008409, 28510447, 29351928
S1336	Phosphorylation		score1	PhosphoSitePlus
T1337	Phosphorylation		score3	neXtProt PhosphoSitePlus	21685893
T1337	Phosphorylation	P41743 (PRKCI)	score2	neXtProt	21685893
S1341	Phosphorylation		score3	neXtProt PhosphoSitePlus	21685893
S1341	Phosphorylation	P41743 (PRKCI)	score2	neXtProt	21685893

Q13464 (ROCK1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O00429 (DNM1L)	S637	score2	neXtProt	22326220
O14649 (KCNK3)	S336	score1	Signor	21838752
O14649 (KCNK3)	S393	score1	Signor	21838752
O14950 (MYL12B)	T19	score4	PhosphoSitePlus Signor	15226371, 12185584
O14950 (MYL12B)	S20	score4	PhosphoSitePlus Signor	12185584, 15676024, 15226371, ...18648664, 10233893
O14974-1 (PPP1R12A)	T696	score4	HPRD phospho.ELM PhosphoSitePlus Signor	8662509, 18212344, 11719507, ...18767875, 11931630, 15281089, 12600888, 12220642, 18669648, 10601309, 11384979, 18077418
O14974 (PPP1R12A)	S852	score3	PhosphoSitePlus	15676024, 10926869
O14974-1 (PPP1R12A)	T853	score4	HPRD PhosphoSitePlus	10601309, 12220642, 19255442, ...12563012
O43293 (DAPK3)	T265	score3	neXtProt PhosphoSitePlus	17158456
O43293 (DAPK3)	T299	score4	neXtProt PhosphoSitePlus	17158456, 20854903
O60237 (PPP1R12B)	T646	score4	PhosphoSitePlus Signor	22937917, 16431080
P04637 (TP53)	S15	score2	RLIMS-P+	28131915
P07737 (PFN1)	S138	score4	neXtProt PhosphoSitePlus Signor	22479341, 18573880
P08670 (VIM)	S72	score4	HPRD phospho.ELM PhosphoSitePlus	15676024, 19007248, 18669648, ...9565595, 20166139, 23737341, 20068231
P14136-1 (GFAP)	T7	score4	HPRD phospho.ELM PhosphoSitePlus	12686604, 9099667
P14136-1 (GFAP)	S13	score4	HPRD phospho.ELM PhosphoSitePlus	7822264, 12686604, 9099667, ...2155236, 2114109
P14136-1 (GFAP)	S17	score2	HPRD	7822264, 2155236, 2114109
P14136-1 (GFAP)	S38	score4	HPRD phospho.ELM PhosphoSitePlus	7822264, 12686604, 9099667, ...2155236, 2114109
P15311 (EZR)	T567	score4	HPRD phospho.ELM PhosphoSitePlus Signor	10970850, 19255442, 21979959, ...11387207, 19386264
P17661 (DES)	S12	score2	PhosphoSitePlus	12686604
P17661 (DES)	T17	score4	HPRD PhosphoSitePlus Signor	12686604, 10574968
P17661 (DES)	S60	score2	PhosphoSitePlus	12686604
P17661 (DES)	T76	score4	HPRD PhosphoSitePlus Signor	12686604, 10574968
P17661 (DES)	T77	score4	HPRD PhosphoSitePlus Signor	12686604, 10574968
P19105 (MYL12A)	T18	score3	phospho.ELM Signor	12185584
P19105 (MYL12A)	S19	score3	phospho.ELM Signor	12185584
P19634 (SLC9A1)	T653	score2	PhosphoSitePlus	25578862
P24844 (MYL9)	T19	score2	PhosphoSitePlus	26169356
P24844 (MYL9)	S20	score4	PhosphoSitePlus Signor	26169356, 12802051, 8702756
P26038 (MSN)	T558	score4	HPRD PhosphoSitePlus	19255442, 9516463, 9856983
P29966 (MARCKS)	S159	score2	PhosphoSitePlus	11162562
P35241-1 (RDX)	T564	score4	HPRD PhosphoSitePlus	9456324, 19255442, 15676024, ...20068231
P35241-1 (RDX)	T573	score1	HPRD	9456324
P35611 (ADD1)	T445	score3	HPRD phospho.ELM PhosphoSitePlus Signor	10209029
P35611-1 (ADD1)	T480	score3	HPRD PhosphoSitePlus Signor	10209029
P35611-3 (ADD1)	T511	score1	HPRD	10209029
P48436 (SOX9)	S181	score3	phospho.ELM PhosphoSitePlus Signor	20039424
P49815 (TSC2)	T1203	score2	RLIMS-P+	21561859
P53667-1 (LIMK1)	T508	score4	HPRD neXtProt PhosphoSitePlus Signor	11340065, 10559936, 10652353
P53671 (LIMK2)	T505	score4	HPRD neXtProt PhosphoSitePlus Signor	11340065, 11171090, 11018042
P53671-1 (LIMK2)	T526	score2	HPRD	11340065, 11018042
P60484 (PTEN)	S229	score3	phospho.ELM PhosphoSitePlus Signor	15793569
P60484 (PTEN)	T232	score3	phospho.ELM PhosphoSitePlus Signor	15793569
P61587 (RND3)	S7	score2	PhosphoSitePlus	15775972
P61587 (RND3)	S11	score3	PhosphoSitePlus Signor	15775972
P61587 (RND3)	S218	score2	PhosphoSitePlus	23622247
P61587 (RND3)	S240	score2	PhosphoSitePlus	23622247
Q05397 (PTK2)	S732	score3	neXtProt phospho.ELM PhosphoSitePlus	16760434
Q14160 (SCRIB)	S1378	score2	PhosphoSitePlus	26101221
Q14160 (SCRIB)	S1508	score2	PhosphoSitePlus	26101221
Q16555 (DPYSL2)	T555	score4	HPRD PhosphoSitePlus	22443207, 10818093
Q8N264-1 (ARHGAP24)	S391	score3	HPRD neXtProt PhosphoSitePlus Signor	16862148
Q8N264-1 (ARHGAP24)	S402	score3	HPRD neXtProt PhosphoSitePlus Signor	16862148
Q8N264 (ARHGAP24)	S413	score3	HPRD neXtProt PhosphoSitePlus Signor	16862148
Q8N264 (ARHGAP24)	S415	score3	HPRD neXtProt PhosphoSitePlus Signor	16862148
Q8N264 (ARHGAP24)	S437	score3	HPRD neXtProt PhosphoSitePlus Signor	16862148
Q8N264 (ARHGAP24)	T452	score3	HPRD neXtProt PhosphoSitePlus Signor	16862148
Q8N264 (ARHGAP24)	S573	score2	HPRD Signor	16862148
Q8N264 (ARHGAP24)	S574	score2	HPRD Signor	16862148
Q8N264 (ARHGAP24)	T575	score2	HPRD Signor	16862148
Q8N264-1 (ARHGAP24)	T576	score2	HPRD Signor	16862148
Q8N264 (ARHGAP24)	T577	score2	HPRD Signor	16862148
Q9NRY4 (ARHGAP35)	S1150	score3	PhosphoSitePlus Signor	19103606
Q9NRY4 (ARHGAP35)	T1173	score2	PhosphoSitePlus	19103606
Q9NRY4 (ARHGAP35)	S1174	score2	PhosphoSitePlus	19103606
Q9NRY4 (ARHGAP35)	T1226	score2	PhosphoSitePlus	19103606
Q9NRY4 (ARHGAP35)	S1236	score3	PhosphoSitePlus Signor	19103606
Q9UPT6 (MAPK8IP3)	S314	score4	PhosphoSitePlus Signor	15767678, 19036714
Q9UPT6 (MAPK8IP3)	S364	score4	PhosphoSitePlus Signor	15767678, 19036714
Q9UPT6 (MAPK8IP3)	S365	score4	PhosphoSitePlus Signor	15767678, 19036714
Q9Y613 (FHOD1)	S1131	score3	PhosphoSitePlus Signor	18239683
Q9Y613 (FHOD1)	S1137	score3	PhosphoSitePlus Signor	18239683
Q9Y613 (FHOD1)	T1141	score3	PhosphoSitePlus Signor	18239683

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	P12931 (SRC)	S43	Q13464 (ROCK1)	unknown	eFIP	33388549

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K65	E65	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K65	N65	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
K65	I65	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K109	E109	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K109	I109	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S118	F118	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K225	*	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T398	I398	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S407	C407	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
T455	N455	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T455	I455	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S533	*	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S572	N572	Biomuta	DOID:363 / uterine cancer [ icgc ]
S574	L574	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S679	*	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K718	T718	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K857	T857	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K921	N921	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
K950	N950	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
S1098	L1098	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S1100	F1100	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
S1100	C1100	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S1105	G1105	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T1112	P1112	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y1153	C1153	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1180	N1180	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K1194	*	Biomuta	DOID:1612 / breast cancer [ cosmic ]
T1331	M1331	Biomuta	DOID:363 / uterine cancer [ cosmic ]
S1341	F1341	Biomuta	DOID:10283 / prostate cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q13464 (ROCK1)

Protein Information

Interactive Sequence View

Q13464 (ROCK1) as Substrate

Q13464 (ROCK1) as PTM Enzyme

PTM-dependent PPI

PTM sites affected in variants