iPTMnet Report for Q13227 (GPS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13227 / GPS2_HUMAN
Protein Name G protein pathway suppressor 2
Gene Name Name: GPS2
Organism Homo sapiens (Human)

PRO ID PR:Q13227
DAG View
PRO Name G protein pathway suppressor 2 (human)
Definition A G protein pathway suppressor 2 that is encoded in the genome of human.
Short Label hGPS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13227 (GPS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K66 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
T161 O-Glycosylation GlyGen 33214551, 30379171, 31492838, ...35254053, 34019948, 28657654, 30059200
S205 Phosphorylation PhosphoSitePlus
R312 Methylation PhosphoSitePlus   UniProt 24129315
R323 Methylation IEDB   PhosphoSitePlus   UniProt 22869377, 24129315, 19917673


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K91 N91 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K91 T91 Biomuta DOID:1319 / brain cancer [ cosmic ]
K151 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R312 W312 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R323 Q323 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
R323 * Biomuta DOID:363 / uterine cancer [ cosmic ]