iPTMnet Report for Q13158 (FADD)
Protein Information
UniProt AC / UniProt ID | Q13158 / FADD_HUMAN |
Protein Name | FAS-associated death domain protein |
Gene Name | Name: FADD Synonyms:MORT1;ORFNames:GIG3; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q13158 |
PRO Name | FAS-associated death domain protein (human) |
Definition | A FAS-associated death domain protein that is encoded in the genome of human. |
Short Label | hFADD |
Category | organism-gene |
Q13158 (FADD) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S16 | Phosphorylation | score0 | RLIMS-P | 23606538 | ||
S18 | Phosphorylation | score0 | HPRD | 20068231 | ||
T21 | Phosphorylation | score0 | HPRD | 20068231 | ||
S41 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20166139 | ||
S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
K120 | Sumoylation | score1 | PhosphoSitePlus | |||
K125 | Sumoylation | score1 | PhosphoSitePlus | |||
K125 | Ubiquitination | score1 | PhosphoSitePlus | |||
R132 | Methylation | score1 | PhosphoSitePlus | |||
Y133 | Phosphorylation | score1 | PhosphoSitePlus | |||
T138 | Phosphorylation | score1 | PhosphoSitePlus | |||
K149 | Sumoylation | score1 | PhosphoSitePlus | |||
K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
K153 | Ubiquitination | score1 | PhosphoSitePlus | |||
T157 | Phosphorylation | score1 | PhosphoSitePlus | |||
R166 | Methylation | score1 | PhosphoSitePlus | |||
S167 | Phosphorylation | score1 | PhosphoSitePlus | |||
S190 | Phosphorylation | score1 | PhosphoSitePlus | |||
S194 | Phosphorylation | P53350 (PLK1) , O14733 (MAP2K7) , Q9H422 (HIPK3) , P48729 (CSNK1A1) , Q13233 (MAP3K1) | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21315423, 10640736, 16061179, ... | |
S197 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19413330 | ||
S200 | Phosphorylation | P67870 (CSNK2B) | score3 | PhosphoSitePlus RLIMS-P | 26253696 | |
S203 | Phosphorylation | O14965 (AURKA) | score3 | PhosphoSitePlus RLIMS-P Signor | 21978935 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | Q15121 (PEA15) | S104 | Q13158 (FADD) | increased_association | eFIP | 15916534 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S69 | F69 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K125 | N125 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
K149 | N149 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ] | |
S194 | F194 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S197 | T197 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |