iPTMnet Report for Q13158 (FADD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13158 / FADD_HUMAN
Protein Name FAS-associated death domain protein
Gene Name Name: FADD
Synonyms:MORT1;ORFNames:GIG3;
Organism Homo sapiens (Human)

PRO ID PR:Q13158
DAG View
PRO Name FAS-associated death domain protein (human)
Definition A FAS-associated death domain protein that is encoded in the genome of human.
Short Label hFADD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13158 (FADD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation RLIMS-P 23606538
S18 Phosphorylation HPRD 20068231
T21 Phosphorylation HPRD 20068231
S41 Phosphorylation HPRD   PhosphoSitePlus 20166139
S69 Phosphorylation PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
K125 Sumoylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
R132 Methylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
K149 Sumoylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
R166 Methylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S194 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21315423, 10640736, 16061179, ...11034606, 19955841, 19303913, 21406692, 23186163, 20230923, 21978935, 20420860, 20890306, 19690332, 19413330, 19664995, 24548998, 25790448, 23285096, 15906275, 15001534, 20068231
S194 Phosphorylation O14733 (MAP2K7) PhosphoSitePlus   Signor 15001534
S194 Phosphorylation P48729 (CSNK1A1) HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 20230923, 10640736, ...19664995, 16061179, 20420860, 11034606, 20068231
S194 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 20890306, 21978935
S194 Phosphorylation Q13233 (MAP3K1) PhosphoSitePlus   Signor 15001534
S194 Phosphorylation Q9H422 (HIPK3) HPRD   phospho.ELM 19413330, 20230923, 19664995, ...10640736, 11034606, 20068231
S197 Phosphorylation HPRD   PhosphoSitePlus 19413330
S200 Phosphorylation PhosphoSitePlus   RLIMS-P 26253696
S200 Phosphorylation P67870 (CSNK2B) PhosphoSitePlus 26253696
S203 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 21978935
S203 Phosphorylation O14965 (AURKA) PhosphoSitePlus   Signor 21978935


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15121 (PEA15) S104 Q13158 (FADD) increased_association eFIP 15916534


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S69 F69 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K125 N125 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K149 N149 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S194 F194 Biomuta DOID:1324 / lung cancer [ cosmic ]
S197 T197 Biomuta DOID:4159 / skin cancer [ cosmic ]