iPTMnet Report Q13158 FADD

Protein Information

UniProt AC / UniProt ID	Q13158 / FADD_HUMAN
Protein Name	FAS-associated death domain protein
Gene Name	Name: FADD Synonyms:MORT1;ORFNames:GIG3;
Organism	Homo sapiens (Human)

PRO ID	PR:Q13158 DAG View
PRO Name	FAS-associated death domain protein (human)
Definition	A FAS-associated death domain protein that is encoded in the genome of human.
Short Label	hFADD
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q13158 (FADD) as Substrate

Q13158

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S16 S18 T21 S41 S69 K120 K125 R132 Y133 T138 K149 K153 T157 R166 S167 S190 S194 S197 S200 S203	PTM Type Select all Methylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme Select all O14733 (MAP2K7) O14965 (AURKA) P48729 (CSNK1A1) P53350 (PLK1) P67870 (CSNK2B) Q13233 (MAP3K1) Q9H422 (HIPK3)	Score Select all 0 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
S16	Phosphorylation		score0	RLIMS-P	23606538
S18	Phosphorylation		score0	HPRD	20068231
T21	Phosphorylation		score0	HPRD	20068231
S41	Phosphorylation		score2	HPRD PhosphoSitePlus	20166139
S69	Phosphorylation		score1	PhosphoSitePlus
K120	Sumoylation		score1	PhosphoSitePlus
K125	Sumoylation		score1	PhosphoSitePlus
K125	Ubiquitination		score1	PhosphoSitePlus
R132	Methylation		score1	PhosphoSitePlus
Y133	Phosphorylation		score1	PhosphoSitePlus
T138	Phosphorylation		score1	PhosphoSitePlus
K149	Sumoylation		score1	PhosphoSitePlus
K149	Ubiquitination		score1	PhosphoSitePlus
K153	Ubiquitination		score1	PhosphoSitePlus
T157	Phosphorylation		score1	PhosphoSitePlus
R166	Methylation		score1	PhosphoSitePlus
S167	Phosphorylation		score1	PhosphoSitePlus
S190	Phosphorylation		score1	PhosphoSitePlus
S194	Phosphorylation		score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	21315423, 10640736, 16061179, ...11034606, 19955841, 19303913, 21406692, 23186163, 20230923, 21978935, 20420860, 20890306, 19690332, 19413330, 19664995, 24548998, 25790448, 23285096, 15906275, 15001534, 20068231
S194	Phosphorylation	O14733 (MAP2K7)	score3	PhosphoSitePlus Signor	15001534
S194	Phosphorylation	P48729 (CSNK1A1)	score4	HPRD neXtProt PhosphoSitePlus Signor	19413330, 20230923, 10640736, ...19664995, 16061179, 20420860, 11034606, 20068231
S194	Phosphorylation	P53350 (PLK1)	score4	PhosphoSitePlus Signor	20890306, 21978935
S194	Phosphorylation	Q13233 (MAP3K1)	score3	PhosphoSitePlus Signor	15001534
S194	Phosphorylation	Q9H422 (HIPK3)	score4	HPRD phospho.ELM	19413330, 20230923, 19664995, ...10640736, 11034606, 20068231
S197	Phosphorylation		score2	HPRD PhosphoSitePlus	19413330
S200	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	26253696
S200	Phosphorylation	P67870 (CSNK2B)	score2	PhosphoSitePlus	26253696
S203	Phosphorylation		score3	PhosphoSitePlus RLIMS-P Signor	21978935
S203	Phosphorylation	O14965 (AURKA)	score3	PhosphoSitePlus Signor	21978935

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q15121 (PEA15)	Site Select all By amino acid All Serine By position S104	Interactant Select all Q13158 (FADD)	Association type Select all increased_association	Source Select all eFIP	PMID
	Phosphorylation	Q15121 (PEA15)	S104	Q13158 (FADD)	increased_association	eFIP	15916534

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position S69 K125 K149 S194 S197	Variant Select all F194 F69 N125 N149 T197	Source Select all Biomuta	Disease [Sample source] Select all DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S69	F69	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K125	N125	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
K149	N149	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S194	F194	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S197	T197	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q13158 (FADD)

Protein Information

Interactive Sequence View

Q13158 (FADD) as Substrate

PTM-dependent PPI

PTM sites affected in variants