iPTMnet Report Q12852 MAP3K12

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q12852 / M3K12_HUMAN
Protein Name	Mitogen-activated protein kinase kinase kinase 12
Gene Name	Name: MAP3K12 Synonyms:ZPK;
Organism	Homo sapiens (Human)

PRO ID	PR:Q12852 DAG View
PRO Name	mitogen-activated protein kinase kinase kinase 12 (human)
Definition	A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human.
Short Label	hMAP3K12
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q12852 (MAP3K12) as Substrate

Q12852

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T9	Phosphorylation		score0	RLIMS-P	23979718
	S11	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	23979718
	T43	Phosphorylation		score0	RLIMS-P	23979718
	S477	Phosphorylation		score1	PhosphoSitePlus
	S500	Phosphorylation		score1	PhosphoSitePlus
	S503	Phosphorylation		score1	IEDB	35494241
	S536	Phosphorylation		score1	PhosphoSitePlus
	S551	Phosphorylation		score1	PhosphoSitePlus
	S555	Phosphorylation		score1	PhosphoSitePlus
	S609	Phosphorylation		score1	PhosphoSitePlus
	S615	Phosphorylation		score1	PhosphoSitePlus
	S634	Phosphorylation		score1	PhosphoSitePlus
	T642	Phosphorylation		score1	PhosphoSitePlus
	S645	Phosphorylation		score1	PhosphoSitePlus
	S695	Phosphorylation		score1	PhosphoSitePlus
	T699	Phosphorylation		score1	PhosphoSitePlus
	S757	Phosphorylation		score1	PhosphoSitePlus

Q12852 (MAP3K12) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O14950 (MYL12B)	T19	score4	PhosphoSitePlus Signor	11384979, 11781833
	O14950 (MYL12B)	S20	score2	PhosphoSitePlus	11384979

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S11	F11	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S477	F477	Biomuta		DOID:1612 / breast cancer [ cosmic ]
S536	P536	Biomuta		DOID:1612 / breast cancer [ cosmic ]
S536	L536	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S551	N551	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S609	L609	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ]
S645	G645	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S695	F695	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic ]
T699	N699	Biomuta		DOID:5041 / esophageal cancer [ cosmic, icgc ]