Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12852 / M3K12_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 12
Gene Name Name: MAP3K12
Synonyms:ZPK;
Organism Homo sapiens (Human)

PRO ID PR:Q12852
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 12 (human)
Definition A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human.
Short Label hMAP3K12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12852 (MAP3K12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation RLIMS-P 23979718
S11 Phosphorylation PhosphoSitePlus   RLIMS-P 23979718
T43 Phosphorylation RLIMS-P 23979718
S477 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
T699 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus


Q12852 (MAP3K12) as PTM Enzyme



Substrate Site Score Source PMID
O14950 (MYL12B) T19 PhosphoSitePlus   Signor 11384979, 11781833
O14950 (MYL12B) S20 PhosphoSitePlus 11384979


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T9 K9 Biomuta DOID:3571 / liver cancer [ icgc ]
S11 F11 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S11 T11 Biomuta DOID:1324 / lung cancer [ tcga ]
S536 L536 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S609 L609 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S645 G645 Biomuta DOID:1909 / melanoma [ cosmic ]