iPTMnet Report for Q12852 (MAP3K12)
Protein Information
| UniProt AC / UniProt ID | Q12852 / M3K12_HUMAN |
| Protein Name | Mitogen-activated protein kinase kinase kinase 12 |
| Gene Name | Name: MAP3K12 Synonyms:ZPK; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q12852 |
| PRO Name | mitogen-activated protein kinase kinase kinase 12 (human) |
| Definition | A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human. |
| Short Label | hMAP3K12 |
| Category | organism-gene |
DAG ViewQ12852 (MAP3K12) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T9 | Phosphorylation | score0 | RLIMS-P | 23979718 | ||
| S11 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 23979718 | ||
| T43 | Phosphorylation | score0 | RLIMS-P | 23979718 | ||
| S477 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S500 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S503 | Phosphorylation | score1 | IEDB | 35494241 | ||
| S536 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S551 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S555 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S609 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S615 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S634 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T642 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S645 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S695 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T699 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S757 | Phosphorylation | score1 | PhosphoSitePlus |
Q12852 (MAP3K12) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O14950 (MYL12B) | T19 | score4 | PhosphoSitePlus Signor | 11384979, 11781833 | |
| O14950 (MYL12B) | S20 | score2 | PhosphoSitePlus | 11384979 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S11 | F11 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S477 | F477 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S536 | P536 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S536 | L536 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S551 | N551 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S609 | L609 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S645 | G645 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S695 | F695 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| T699 | N699 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] |
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