iPTMnet Report for Q08AE8 (SPIRE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08AE8 / SPIR1_HUMAN
Protein Name Protein spire homolog 1
Gene Name Name: SPIRE1
Synonyms:KIAA1135,SPIR1;
Organism Homo sapiens (Human)

PRO ID PR:Q08AE8
DAG View
PRO Name protein spire homolog 1 (human)
Definition A protein spire homolog 1 that is encoded in the genome of human.
Short Label hSPIRE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08AE8 (SPIRE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S84 Phosphorylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus   UniProt 23186163
S441 Phosphorylation PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus   UniProt 18669648
S465 Phosphorylation PhosphoSitePlus   UniProt 18669648
S467 Phosphorylation PhosphoSitePlus   UniProt 18669648
T471 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus   UniProt 23186163
S523 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
Y578 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus   UniProt 23186163
S682 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S387 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S450 Phosphorylation HPRD 19651622, 18669648, 18452278
S451 Phosphorylation HPRD 19651622, 18669648, 18452278
S453 Phosphorylation HPRD 19651622, 18669648, 18452278
T457 Phosphorylation HPRD 18669648
T495 Phosphorylation HPRD 19664994
S701 Phosphorylation HPRD 20058876
S702 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S451 Y451 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T457 A457 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
T458 A458 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T458 S458 Biomuta DOID:4159 / skin cancer [ cosmic ]
S465 Y465 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T471 A471 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
T495 I495 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T495 S495 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T495 A495 Biomuta DOID:1319 / brain cancer [ cosmic ]
S508 P508 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T509 S509 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T509 I509 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T509 A509 Biomuta DOID:1319 / brain cancer [ cosmic ]
S523 F523 Biomuta DOID:4159 / skin cancer [ cosmic ]
S545 F545 Biomuta DOID:4159 / skin cancer [ cosmic ]
S678 Y678 Biomuta DOID:363 / uterine cancer [ icgc ]
S682 L682 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S682 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S710 L710 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S740 L740 Biomuta DOID:9256 / colorectal cancer [ cosmic ]