iPTMnet Report Q08AE8 SPIRE1

Protein Information

UniProt AC / UniProt ID	Q08AE8 / SPIR1_HUMAN
Protein Name	Protein spire homolog 1
Gene Name	Name: SPIRE1 Synonyms:KIAA1135,SPIR1;
Organism	Homo sapiens (Human)

PRO ID	PR:Q08AE8 DAG View
PRO Name	protein spire homolog 1 (human)
Definition	A protein spire homolog 1 that is encoded in the genome of human.
Short Label	hSPIRE1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q08AE8 (SPIRE1) as Substrate

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position A2 S84 K246 K247 S336 T362 S387 S441 T442 T458 S464 S465 S467 T471 S508 T509 S523 S545 Y578 S652 S668 S676 S678 S682 S710 S715 S716 S719 S735 S740	PTM Type Select all Acetylation Phosphorylation	Score Select all 1 2	Source Select all PhosphoSitePlus UniProt	PMID
A2	Acetylation	score1	UniProt	22814378
S84	Phosphorylation	score1	PhosphoSitePlus
K246	Acetylation	score1	PhosphoSitePlus
K247	Acetylation	score1	PhosphoSitePlus
S336	Phosphorylation	score1	PhosphoSitePlus
T362	Phosphorylation	score1	PhosphoSitePlus
S387	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S441	Phosphorylation	score1	PhosphoSitePlus
T442	Phosphorylation	score1	PhosphoSitePlus
T458	Phosphorylation	score1	PhosphoSitePlus
S464	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648
S465	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648
S467	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648
T471	Phosphorylation	score1	PhosphoSitePlus
S508	Phosphorylation	score1	PhosphoSitePlus
T509	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S523	Phosphorylation	score1	PhosphoSitePlus
S545	Phosphorylation	score1	PhosphoSitePlus
Y578	Phosphorylation	score1	PhosphoSitePlus
S652	Phosphorylation	score1	PhosphoSitePlus
S668	Phosphorylation	score1	PhosphoSitePlus
S676	Phosphorylation	score1	PhosphoSitePlus
S678	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S682	Phosphorylation	score1	PhosphoSitePlus
S710	Phosphorylation	score1	PhosphoSitePlus
S715	Phosphorylation	score1	PhosphoSitePlus
S716	Phosphorylation	score1	PhosphoSitePlus
S719	Phosphorylation	score1	PhosphoSitePlus
S735	Phosphorylation	score1	PhosphoSitePlus
S740	Phosphorylation	score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine By position S387 S394 T400 S403 S450 S451 S453 T457 T495 S701 S702	PTM Type Select all Phosphorylation	Score Select all 0 1	Source Select all HPRD PhosphoSitePlus	PMID
S387	Phosphorylation	score1	PhosphoSitePlus
S394	Phosphorylation	score1	PhosphoSitePlus
T400	Phosphorylation	score1	PhosphoSitePlus
S403	Phosphorylation	score1	PhosphoSitePlus
S450	Phosphorylation	score0	HPRD	19651622, 18669648, 18452278
S451	Phosphorylation	score0	HPRD	19651622, 18669648, 18452278
S453	Phosphorylation	score0	HPRD	19651622, 18669648, 18452278
T457	Phosphorylation	score0	HPRD	18669648
T495	Phosphorylation	score0	HPRD	19664994
S701	Phosphorylation	score0	HPRD	20058876
S702	Phosphorylation	score0	HPRD	20058876

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S451 T457 T458 S465 T471 T495 S508 T509 S523 S545 S678 S682 S710 S740	Variant Select all * A457 A458 A471 A495 A509 F523 F545 I495 I509 L682 L710 L740 P508 S458 S495 S509 Y451 Y465 Y678	Source Select all Biomuta	Disease [Sample source] Select all DOID:1319 / brain cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S451	Y451	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
T457	A457	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
T458	A458	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
T458	S458	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S465	Y465	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
T471	A471	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
T495	I495	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
T495	S495	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
T495	A495	Biomuta	DOID:1319 / brain cancer [ cosmic ]
S508	P508	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
T509	S509	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
T509	I509	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
T509	A509	Biomuta	DOID:1319 / brain cancer [ cosmic ]
S523	F523	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S545	F545	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S678	Y678	Biomuta	DOID:363 / uterine cancer [ icgc ]
S682	L682	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S682	*	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S710	L710	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S740	L740	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q08AE8 (SPIRE1)

Protein Information

Interactive Sequence View

Q08AE8 (SPIRE1) as Substrate

PTM sites affected in variants