iPTMnet Report for Q08289 (CACNB2)
Protein Information
UniProt AC / UniProt ID | Q08289 / CACB2_HUMAN |
Protein Name | Voltage-dependent L-type calcium channel subunit beta-2 |
Gene Name | Name: CACNB2 Synonyms:CACNLB2,MYSB; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q08289 |
PRO Name | voltage-dependent L-type calcium channel subunit beta-2 (human) |
Definition | A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human. |
Short Label | hCACNB2 |
Category | organism-gene |
Q08289 (CACNB2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S58 | Phosphorylation | score1 | PhosphoSitePlus | |||
T219 | Phosphorylation | score2 | phospho.ELM | 10441130 | ||
T269 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y275 | Phosphorylation | score1 | PhosphoSitePlus | |||
S280 | Phosphorylation | score1 | PhosphoSitePlus | |||
T464 | Phosphorylation | score1 | PhosphoSitePlus | |||
T482 | Phosphorylation | score1 | PhosphoSitePlus | |||
S484 | Phosphorylation | score1 | PhosphoSitePlus | |||
S514 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus | 10441130, 10567342 | ||
S533 | Phosphorylation | score3 | phospho.ELM | 10441130, 10567342 | ||
S534 | Phosphorylation | score3 | phospho.ELM | 10441130, 10567342 | ||
S543 | Phosphorylation | score1 | PhosphoSitePlus | |||
T545 | Phosphorylation | score1 | PhosphoSitePlus | |||
S546 | Phosphorylation | score1 | PhosphoSitePlus | |||
S550 | O-Glycosylation | score1 | GlyGen | 31492838 | ||
S550 | Phosphorylation | score1 | PhosphoSitePlus | |||
T554 | Phosphorylation | score3 | PhosphoSitePlus Signor | 20194790 | ||
T554 | Phosphorylation | Q13557 (CAMK2D) | score1 | Signor | 20194790 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T219 | Phosphorylation | score1 | HPRD | 10441130 | ||
T219 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S514 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S514 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S533 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S533 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S534 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S534 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S152 | Phosphorylation | score1 | PhosphoSitePlus | |||
T164 | Phosphorylation | score3 | HPRD PhosphoSitePlus | 10441130 | ||
T164 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S459 | Phosphorylation | score4 | HPRD neXtProt | 10441130, 10567342 | ||
S459 | Phosphorylation | P17612 (PRKACA) | score4 | HPRD neXtProt | 10441130, 10567342 | |
S478 | Phosphorylation | score4 | HPRD neXtProt | 10441130, 10567342 | ||
S478 | Phosphorylation | P17612 (PRKACA) | score4 | HPRD neXtProt | 10441130, 10567342 | |
S479 | Phosphorylation | score4 | HPRD neXtProt | 10441130, 10567342 | ||
S479 | Phosphorylation | P17612 (PRKACA) | score4 | HPRD neXtProt | 10441130, 10567342 | |
T499 | Phosphorylation | score2 | PhosphoSitePlus | 20194790 | ||
T499 | Phosphorylation | Q13557 (CAMK2D) | score2 | PhosphoSitePlus | 20194790 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T165 | Phosphorylation | score1 | HPRD | 10441130 | ||
T165 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S460 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S460 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S479 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S479 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S480 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S480 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T191 | Phosphorylation | score1 | HPRD | 10441130 | ||
T191 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S486 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S486 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S505 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S505 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S506 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S506 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T171 | Phosphorylation | score1 | HPRD | 10441130 | ||
T171 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S466 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S466 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S485 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S485 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S486 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S486 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T219 | Phosphorylation | score1 | HPRD | 10441130 | ||
T219 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S476 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S476 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S495 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S495 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S496 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S496 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T219 | Phosphorylation | score1 | HPRD | 10441130 | ||
T219 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S490 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S490 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S509 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S509 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S510 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S510 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T191 | Phosphorylation | score1 | HPRD | 10441130 | ||
T191 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10441130 | |
S462 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S462 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S482 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S482 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 | |
S483 | Phosphorylation | score2 | HPRD | 10441130, 10567342 | ||
S483 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10441130, 10567342 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T269 | K269 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
T464 | N464 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S478 | F478 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S479 | F479 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S483 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S483 | L483 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
S484 | C484 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S485 | F485 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S505 | F505 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S509 | F509 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S533 | F533 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S543 | I543 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S550 | P550 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |