iPTMnet Report Q08289 CACNB2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q08289 / CACB2_HUMAN
Protein Name	Voltage-dependent L-type calcium channel subunit beta-2
Gene Name	Name: CACNB2 Synonyms:CACNLB2,MYSB;
Organism	Homo sapiens (Human)

PRO ID	PR:Q08289 DAG View
PRO Name	voltage-dependent L-type calcium channel subunit beta-2 (human)
Definition	A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human.
Short Label	hCACNB2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q08289 (CACNB2) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S58	Phosphorylation		score1	PhosphoSitePlus
	T219	Phosphorylation		score2	phospho.ELM	10441130
	T269	Phosphorylation		score1	PhosphoSitePlus
	Y275	Phosphorylation		score1	PhosphoSitePlus
	S280	Phosphorylation		score1	PhosphoSitePlus
	T464	Phosphorylation		score1	PhosphoSitePlus
	T482	Phosphorylation		score1	PhosphoSitePlus
	S484	Phosphorylation		score1	PhosphoSitePlus
	S514	Phosphorylation		score4	phospho.ELM PhosphoSitePlus	10441130, 10567342
	S533	Phosphorylation		score3	phospho.ELM	10441130, 10567342
	S534	Phosphorylation		score3	phospho.ELM	10441130, 10567342
	S543	Phosphorylation		score1	PhosphoSitePlus
	T545	Phosphorylation		score1	PhosphoSitePlus
	S546	Phosphorylation		score1	PhosphoSitePlus
	S550	O-Glycosylation		score1	GlyGen	31492838
	S550	Phosphorylation		score1	PhosphoSitePlus
	T554	Phosphorylation	Q13557 (CAMK2D)	score3	PhosphoSitePlus Signor	20194790

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T219	Phosphorylation	P17612 (PRKACA)	score1	HPRD	10441130
	S514	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S533	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S534	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S152	Phosphorylation		score1	PhosphoSitePlus
	T164	Phosphorylation	P17612 (PRKACA)	score3	HPRD PhosphoSitePlus	10441130
	S459	Phosphorylation	P17612 (PRKACA)	score4	HPRD neXtProt	10441130, 10567342
	S478	Phosphorylation	P17612 (PRKACA)	score4	HPRD neXtProt	10441130, 10567342
	S479	Phosphorylation	P17612 (PRKACA)	score4	HPRD neXtProt	10441130, 10567342
	T499	Phosphorylation	Q13557 (CAMK2D)	score2	PhosphoSitePlus	20194790

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T165	Phosphorylation	P17612 (PRKACA)	score1	HPRD	10441130
	S460	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S479	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S480	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T191	Phosphorylation	P17612 (PRKACA)	score1	HPRD	10441130
	S486	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S505	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S506	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T171	Phosphorylation	P17612 (PRKACA)	score1	HPRD	10441130
	S466	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S485	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S486	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T219	Phosphorylation	P17612 (PRKACA)	score1	HPRD	10441130
	S476	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S495	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S496	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T219	Phosphorylation	P17612 (PRKACA)	score1	HPRD	10441130
	S490	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S509	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S510	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T191	Phosphorylation	P17612 (PRKACA)	score1	HPRD	10441130
	S462	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S482	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342
	S483	Phosphorylation	P17612 (PRKACA)	score2	HPRD	10441130, 10567342

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T269	K269	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
T464	N464	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
S478	F478	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S479	F479	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S483	*	Biomuta		DOID:1612 / breast cancer [ cosmic ]
S483	L483	Biomuta		DOID:1793 / pancreatic cancer [ cosmic ]
S484	C484	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
S485	F485	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S505	F505	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S509	F509	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S533	F533	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S543	I543	Biomuta		DOID:3571 / liver cancer [ cosmic ]
S550	P550	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]