Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08289 / CACB2_HUMAN
Protein Name Voltage-dependent L-type calcium channel subunit beta-2
Gene Name Name: CACNB2
Synonyms:CACNLB2,MYSB;
Organism Homo sapiens (Human)

PRO ID PR:Q08289
DAG View
PRO Name voltage-dependent L-type calcium channel subunit beta-2 (human)
Definition A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human.
Short Label hCACNB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08289 (CACNB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation PhosphoSitePlus
T219 Phosphorylation phospho.ELM 10441130
T269 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
T482 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S514 Phosphorylation phospho.ELM   PhosphoSitePlus 10441130, 10567342
S533 Phosphorylation phospho.ELM 10441130, 10567342
S534 Phosphorylation phospho.ELM 10441130, 10567342
S543 Phosphorylation PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
T554 Phosphorylation Q13557 (CAMK2D) PhosphoSitePlus   Signor 20194790
Site PTM Type PTM Enzyme Score Source PMID
T219 Phosphorylation P17612 (PRKACA) HPRD 10441130
S514 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S533 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S534 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
Site PTM Type PTM Enzyme Score Source PMID
S152 Phosphorylation PhosphoSitePlus
T164 Phosphorylation P17612 (PRKACA) HPRD   PhosphoSitePlus 10441130
S459 Phosphorylation P17612 (PRKACA) HPRD   neXtProt 10441130, 10567342
S478 Phosphorylation P17612 (PRKACA) HPRD   neXtProt 10441130, 10567342
S479 Phosphorylation P17612 (PRKACA) HPRD   neXtProt 10441130, 10567342
T499 Phosphorylation Q13557 (CAMK2D) PhosphoSitePlus 20194790
Site PTM Type PTM Enzyme Score Source PMID
T165 Phosphorylation P17612 (PRKACA) HPRD 10441130
S460 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S479 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S480 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
Site PTM Type PTM Enzyme Score Source PMID
T191 Phosphorylation P17612 (PRKACA) HPRD 10441130
S486 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S505 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S506 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
Site PTM Type PTM Enzyme Score Source PMID
T171 Phosphorylation P17612 (PRKACA) HPRD 10441130
S466 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S485 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S486 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
Site PTM Type PTM Enzyme Score Source PMID
T219 Phosphorylation P17612 (PRKACA) HPRD 10441130
S476 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S495 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S496 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
Site PTM Type PTM Enzyme Score Source PMID
T219 Phosphorylation P17612 (PRKACA) HPRD 10441130
S490 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S509 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S510 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
Site PTM Type PTM Enzyme Score Source PMID
T191 Phosphorylation P17612 (PRKACA) HPRD 10441130
S462 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S482 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342
S483 Phosphorylation P17612 (PRKACA) HPRD 10441130, 10567342


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T464 N464 Biomuta DOID:1324 / lung cancer [ tcga ]
S484 C484 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S543 I543 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S550 P550 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]