iPTMnet Report for Q08043 (ACTN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08043 / ACTN3_HUMAN
Protein Name Alpha-actinin-3
Gene Name Name: ACTN3
Organism Homo sapiens (Human)

PRO ID PR:Q08043
DAG View
PRO Name alpha-actinin-3 (human)
Definition An alpha-actinin-3 that is encoded in the genome of human.
Short Label hACTN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08043 (ACTN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
K45 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
R90 Methylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
S154 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T158 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K209 Sumoylation PhosphoSitePlus
K212 Sumoylation PhosphoSitePlus
Y229 Phosphorylation PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
R275 Methylation PhosphoSitePlus
K278 Acetylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
K506 Acetylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
Y851 Phosphorylation PhosphoSitePlus
Y876 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K49 T49 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S116 R116 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K117 N117 Biomuta DOID:4159 / skin cancer [ cosmic ]
T137 I137 Biomuta DOID:4159 / skin cancer [ cosmic ]
T158 A158 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K209 N209 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R275 S275 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S319 R319 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y333 F333 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S418 F418 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y436 C436 Biomuta DOID:1324 / lung cancer [ cosmic ]
S438 W438 Biomuta DOID:4362 / cervical cancer [ cosmic ]