iPTMnet Report for Q08043 (ACTN3)
Protein Information
UniProt AC / UniProt ID | Q08043 / ACTN3_HUMAN |
Protein Name | Alpha-actinin-3 |
Gene Name | Name: ACTN3 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q08043 |
PRO Name | alpha-actinin-3 (human) |
Definition | An alpha-actinin-3 that is encoded in the genome of human. |
Short Label | hACTN3 |
Category | organism-gene |
Q08043 (ACTN3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 22223895 | ||
K45 | Ubiquitination | score1 | PhosphoSitePlus | |||
K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
K61 | Ubiquitination | score1 | PhosphoSitePlus | |||
T64 | Phosphorylation | score1 | PhosphoSitePlus | |||
R90 | Methylation | score1 | PhosphoSitePlus | |||
R93 | Methylation | score1 | PhosphoSitePlus | |||
S116 | Phosphorylation | score1 | PhosphoSitePlus | |||
K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
T137 | Phosphorylation | score1 | PhosphoSitePlus | |||
S154 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
T158 | Phosphorylation | score1 | PhosphoSitePlus | |||
S159 | Phosphorylation | score1 | PhosphoSitePlus | |||
K209 | Sumoylation | score1 | PhosphoSitePlus | |||
K212 | Sumoylation | score1 | PhosphoSitePlus | |||
Y229 | Phosphorylation | score1 | PhosphoSitePlus | |||
K250 | Acetylation | score1 | PhosphoSitePlus | |||
S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y260 | Phosphorylation | score1 | PhosphoSitePlus | |||
R275 | Methylation | score1 | PhosphoSitePlus | |||
K278 | Acetylation | score1 | PhosphoSitePlus | |||
S298 | Phosphorylation | score1 | PhosphoSitePlus | |||
S319 | Phosphorylation | score1 | PhosphoSitePlus | |||
S321 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y333 | Phosphorylation | score1 | PhosphoSitePlus | |||
T354 | Phosphorylation | score1 | PhosphoSitePlus | |||
T357 | Phosphorylation | score1 | PhosphoSitePlus | |||
S376 | Phosphorylation | score1 | PhosphoSitePlus | |||
S418 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y436 | Phosphorylation | score1 | PhosphoSitePlus | |||
S438 | Phosphorylation | score1 | PhosphoSitePlus | |||
S456 | Phosphorylation | score1 | PhosphoSitePlus | |||
K506 | Acetylation | score1 | PhosphoSitePlus | |||
S737 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y851 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y876 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K49 | T49 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S116 | R116 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K117 | N117 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T137 | I137 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T158 | A158 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
K209 | N209 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R275 | S275 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
S319 | R319 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
Y333 | F333 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
S418 | F418 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y436 | C436 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S438 | W438 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] |