iPTMnet Report for Q07912 (TNK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07912 / ACK1_HUMAN
Protein Name Activated CDC42 kinase 1
Gene Name Name: TNK2
Synonyms:ACK1;
Organism Homo sapiens (Human)

PRO ID PR:Q07912
DAG View
PRO Name activated CDC42 kinase 1 (human)
Definition An activated CDC42 kinase 1 that is encoded in the genome of human.
Short Label hTNK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07912 (TNK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T33 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
S102 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K124 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 14506255, 20623637, ...16472662, 20333297, 21169560, 20979614, 21309750, 26498357, 15308621
Y284 Phosphorylation P12931 (SRC) neXtProt 21309750
Y284 Phosphorylation Q07912 (TNK2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14506255, 20623637, 16472662, ...20333297, 21169560, 20979614, 15308621
S445 Phosphorylation PhosphoSitePlus
T465 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 21169560, 18083107
Y518 Phosphorylation Q07912 (TNK2) neXtProt 21169560
K533 Ubiquitination PhosphoSitePlus
T603 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
Y635 Phosphorylation PhosphoSitePlus   RLIMS-P 25257795
Y635 Phosphorylation P09619 (PDGFRB) PhosphoSitePlus 25257795
S724 Phosphorylation PhosphoSitePlus   UniProt 19369195
S728 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
T814 O-Glycosylation GlyGen 32574038, 32938750, 31492838, ...30620550, 35132862, 35254053, 28657654, 30059200
T817 O-Glycosylation GlyGen 32574038, 31492838, 35254053, ...35132862, 30620550, 28657654, 30059200
T818 O-Glycosylation GlyGen 32574038, 31492838, 35254053, ...35132862, 30620550, 28657654, 30059200
T818 Phosphorylation PhosphoSitePlus
S820 O-Glycosylation GlyGen 32574038, 31492838, 35254053, ...35132862, 30620550, 28657654, 30059200
S823 O-Glycosylation GlyGen 32574038
K826 Acetylation PhosphoSitePlus
Y827 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 21169560
Y827 Phosphorylation Q07912 (TNK2) neXtProt 21169560
T829 Phosphorylation PhosphoSitePlus
R839 Methylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
Y859 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 21169560, 23716717
Y859 Phosphorylation P51813 (BMX) PhosphoSitePlus 23716717
Y859 Phosphorylation Q07912 (TNK2) neXtProt 21169560
Y860 Phosphorylation PhosphoSitePlus 23716717
Y860 Phosphorylation P51813 (BMX) PhosphoSitePlus 23716717
S867 Phosphorylation PhosphoSitePlus
Y868 Phosphorylation PhosphoSitePlus
Y872 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 21169560
Y872 Phosphorylation Q07912 (TNK2) neXtProt 21169560
S881 Phosphorylation PhosphoSitePlus   UniProt 18691976
S898 Phosphorylation IEDB 32387766
T899 Phosphorylation IEDB 32387766
T925 Phosphorylation PhosphoSitePlus
R933 Methylation PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T101 Phosphorylation HPRD 18691976
S102 Phosphorylation HPRD 18669648
Y284 Phosphorylation HPRD 14506255, 17389395
Y284 Phosphorylation P06241 (FYN) HPRD 14506255, 17389395
T517 Phosphorylation HPRD 18691976
Y518 Phosphorylation HPRD 15592455, 19901323, 17389395, ...16497976
S724 Phosphorylation HPRD 18691976, 18669648
S728 Phosphorylation HPRD 18691976, 18669648
S730 Phosphorylation HPRD 18691976, 18669648
S785 Phosphorylation HPRD 18691976
Y827 Phosphorylation HPRD 18691976, 14739304, 18707149
Y859 Phosphorylation HPRD 19901323, 15951569, 17389395
Y860 Phosphorylation HPRD 15951569, 17389395
S881 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus
S806 Phosphorylation HPRD 18691976, 18669648


Q07912 (TNK2) as PTM Enzyme



Substrate Site Score Source PMID
P10275 (AR) Y269 PhosphoSitePlus 17494760, 20623637, 20383201
P10275 (AR) Y365 PhosphoSitePlus 17494760
P31749 (AKT1) Y176 neXtProt   RLIMS-P+ 22322295, 20333297
P31749 (AKT1) T308 RLIMS-P+ 25678401
P31749 (AKT1) S473 RLIMS-P+ 25678401
P42768 (WAS) S277 neXtProt 16257963
P42768 (WAS) Y291 neXtProt   PhosphoSitePlus 16257963, 16472662
P56945 (BCAR1) Y165 neXtProt 16247015, 17038317
P56945 (BCAR1) Y249 neXtProt 16247015, 17038317
P56945 (BCAR1) Y410 neXtProt 16247015, 17038317
Q07912 (TNK2) Y284 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14506255, 20623637, 16472662, ...20333297, 21169560, 20979614, 15308621
Q07912 (TNK2) Y518 neXtProt 21169560
Q07912 (TNK2) Y827 neXtProt 21169560
Q07912 (TNK2) Y859 neXtProt 21169560
Q07912 (TNK2) Y872 neXtProt 21169560
Q9NZC7 (WWOX) Y287 neXtProt   PhosphoSitePlus 16288044
Q9Y4C1 (KDM3A) Y1114 PhosphoSitePlus 25148682
Q9Y5X1 (SNX9) Y56 neXtProt 11773052