Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07912 / ACK1_HUMAN
Protein Name Activated CDC42 kinase 1
Gene Name Name: TNK2
Synonyms:ACK1;
Organism Homo sapiens (Human)

PRO ID PR:Q07912
DAG View
PRO Name activated CDC42 kinase 1 (human)
Definition An activated CDC42 kinase 1 that is encoded in the genome of human.
Short Label hTNK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07912 (TNK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T33 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
S102 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K131 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation Q07912 (TNK2) , P12931 (SRC) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 14506255, 20623637, ...16472662, 20333297, 21169560, 20979614, 21309750, 26498357, 15308621
T465 Phosphorylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation Q07912 (TNK2) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 21169560, 18083107
T603 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
Y635 Phosphorylation P09619 (PDGFRB) PhosphoSitePlus   RLIMS-P 25257795
S724 Phosphorylation PhosphoSitePlus   UniProt 19369195
S728 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
T818 Phosphorylation PhosphoSitePlus
K826 Acetylation PhosphoSitePlus
Y827 Phosphorylation Q07912 (TNK2) neXtProt   PhosphoSitePlus   UniProt 21169560
T829 Phosphorylation PhosphoSitePlus
R839 Methylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
Y859 Phosphorylation Q07912 (TNK2) , P51813 (BMX) neXtProt   PhosphoSitePlus   UniProt 21169560, 23716717
Y860 Phosphorylation P51813 (BMX) PhosphoSitePlus 23716717
S867 Phosphorylation PhosphoSitePlus
Y868 Phosphorylation PhosphoSitePlus
Y872 Phosphorylation Q07912 (TNK2) neXtProt   PhosphoSitePlus   UniProt 21169560
S881 Phosphorylation PhosphoSitePlus   UniProt 18691976
T925 Phosphorylation PhosphoSitePlus
R933 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T101 Phosphorylation HPRD 18691976
S102 Phosphorylation HPRD 18669648
Y284 Phosphorylation P06241 (FYN) HPRD 14506255, 17389395
T517 Phosphorylation HPRD 18691976
Y518 Phosphorylation HPRD 15592455, 19901323, 17389395, ...16497976
S724 Phosphorylation HPRD 18691976, 18669648
S728 Phosphorylation HPRD 18691976, 18669648
S730 Phosphorylation HPRD 18691976, 18669648
S785 Phosphorylation HPRD 18691976
Y827 Phosphorylation HPRD 18691976, 14739304, 18707149
Y859 Phosphorylation HPRD 19901323, 15951569, 17389395
Y860 Phosphorylation HPRD 15951569, 17389395
S881 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
T164 Phosphorylation HPRD 18691976
S165 Phosphorylation HPRD 18669648
Y347 Phosphorylation P06241 (FYN) HPRD 14506255, 17389395
T595 Phosphorylation HPRD 18691976
Y596 Phosphorylation HPRD 15592455, 19901323, 17389395, ...16497976
S802 Phosphorylation HPRD 18691976, 18669648
S806 Phosphorylation HPRD 18691976, 18669648
S808 Phosphorylation HPRD 18691976, 18669648
S863 Phosphorylation HPRD 18691976
Y905 Phosphorylation HPRD 18691976, 14739304, 18707149
Y937 Phosphorylation HPRD 19901323, 15951569, 17389395
Y938 Phosphorylation HPRD 15951569, 17389395
S959 Phosphorylation HPRD 18691976


Q07912 (TNK2) as PTM Enzyme



Substrate Site Score Source PMID
O00401 (WASL) S242 UniProt 16257963
O00401 (WASL) Y256 UniProt 20068231
P10275 (AR) Y269 PhosphoSitePlus   UniProt 17494760, 20623637, 20383201, ...17045208
P10275 (AR) Y365 PhosphoSitePlus   UniProt 17494760, 17045208
P31749 (AKT1) Y176 neXtProt   UniProt 20333297
P42768 (WAS) S277 neXtProt 16257963
P42768 (WAS) Y291 neXtProt   PhosphoSitePlus 16257963, 16472662
P56945 (BCAR1) Y165 neXtProt 16247015, 17038317
P56945 (BCAR1) Y249 neXtProt 16247015, 17038317
P56945 (BCAR1) Y410 neXtProt 16247015, 17038317
Q07912 (TNK2) Y284 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19369195, 14506255, 20623637, ...16472662, 20333297, 21169560, 20979614
Q07912 (TNK2) Y518 neXtProt 21169560
Q07912 (TNK2) Y827 neXtProt 21169560
Q07912 (TNK2) Y859 neXtProt 21169560
Q07912 (TNK2) Y872 neXtProt 21169560
Q9NZC7 (WWOX) Y287 neXtProt   PhosphoSitePlus   UniProt 16288044
Q9Y4C1 (KDM3A) Y1114 PhosphoSitePlus 25148682
Q9Y5X1 (SNX9) Y56 neXtProt 11773052