iPTMnet Report Q07912 TNK2

Protein Information

UniProt AC / UniProt ID	Q07912 / ACK1_HUMAN
Protein Name	Activated CDC42 kinase 1
Gene Name	Name: TNK2 Synonyms:ACK1;
Organism	Homo sapiens (Human)

PRO ID	PR:Q07912 DAG View
PRO Name	activated CDC42 kinase 1 (human)
Definition	An activated CDC42 kinase 1 that is encoded in the genome of human.
Short Label	hTNK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q07912 (TNK2) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T33	Phosphorylation		score1	PhosphoSitePlus
S36	Phosphorylation		score1	PhosphoSitePlus
Y40	Phosphorylation		score1	PhosphoSitePlus
K48	Ubiquitination		score1	PhosphoSitePlus
S74	Phosphorylation		score1	PhosphoSitePlus
S77	Phosphorylation		score1	PhosphoSitePlus
S81	Phosphorylation		score1	PhosphoSitePlus
K100	Ubiquitination		score1	PhosphoSitePlus
T101	Phosphorylation		score1	PhosphoSitePlus
S102	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
K124	Ubiquitination		score1	PhosphoSitePlus
K131	Ubiquitination		score1	PhosphoSitePlus
S136	Phosphorylation		score1	PhosphoSitePlus
S149	Phosphorylation		score1	PhosphoSitePlus
Y193	Phosphorylation		score1	PhosphoSitePlus
T205	Phosphorylation		score1	PhosphoSitePlus
S212	Phosphorylation		score1	PhosphoSitePlus
Y284	Phosphorylation	Q07912 (TNK2) , P12931 (SRC)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	19369195, 14506255, 20623637, ...16472662, 20333297, 21169560, 20979614, 21309750, 26498357, 15308621
S445	Phosphorylation		score1	PhosphoSitePlus
T465	Phosphorylation		score1	PhosphoSitePlus
K515	Ubiquitination		score1	PhosphoSitePlus
T517	Phosphorylation		score1	PhosphoSitePlus
Y518	Phosphorylation	Q07912 (TNK2)	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	15592455, 21169560, 18083107
K533	Ubiquitination		score1	PhosphoSitePlus
T603	Phosphorylation		score1	PhosphoSitePlus
S607	Phosphorylation		score1	PhosphoSitePlus
Y635	Phosphorylation	P09619 (PDGFRB)	score3	PhosphoSitePlus RLIMS-P	25257795
S724	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
S728	Phosphorylation		score1	PhosphoSitePlus
S730	Phosphorylation		score1	PhosphoSitePlus
S774	Phosphorylation		score1	PhosphoSitePlus
S785	Phosphorylation		score1	PhosphoSitePlus
S789	Phosphorylation		score1	PhosphoSitePlus
S810	Phosphorylation		score1	PhosphoSitePlus
T814	O-Glycosylation		score1	GlyGen	32574038, 32938750, 31492838, ...30620550, 35132862, 35254053, 28657654, 30059200
T817	O-Glycosylation		score1	GlyGen	32574038, 31492838, 35254053, ...35132862, 30620550, 28657654, 30059200
T818	O-Glycosylation		score1	GlyGen	32574038, 31492838, 35254053, ...35132862, 30620550, 28657654, 30059200
T818	Phosphorylation		score1	PhosphoSitePlus
S820	O-Glycosylation		score1	GlyGen	32574038, 31492838, 35254053, ...35132862, 30620550, 28657654, 30059200
S823	O-Glycosylation		score1	GlyGen	32574038
K826	Acetylation		score1	PhosphoSitePlus
Y827	Phosphorylation	Q07912 (TNK2)	score3	neXtProt PhosphoSitePlus UniProt	21169560
T829	Phosphorylation		score1	PhosphoSitePlus
R839	Methylation		score1	PhosphoSitePlus
S855	Phosphorylation		score1	PhosphoSitePlus
S856	Phosphorylation		score1	PhosphoSitePlus
T857	Phosphorylation		score1	PhosphoSitePlus
Y859	Phosphorylation	Q07912 (TNK2) , P51813 (BMX)	score4	neXtProt PhosphoSitePlus UniProt	21169560, 23716717
Y860	Phosphorylation	P51813 (BMX)	score2	PhosphoSitePlus	23716717
S867	Phosphorylation		score1	PhosphoSitePlus
Y868	Phosphorylation		score1	PhosphoSitePlus
Y872	Phosphorylation	Q07912 (TNK2)	score3	neXtProt PhosphoSitePlus UniProt	21169560
S881	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976
S898	Phosphorylation		score1	IEDB	32387766
T899	Phosphorylation		score1	IEDB	32387766
T925	Phosphorylation		score1	PhosphoSitePlus
R933	Methylation		score1	PhosphoSitePlus
K1011	Ubiquitination		score1	PhosphoSitePlus
K1037	Ubiquitination		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T101	Phosphorylation		score0	HPRD	18691976
S102	Phosphorylation		score0	HPRD	18669648
Y284	Phosphorylation	P06241 (FYN)	score2	HPRD	14506255, 17389395
T517	Phosphorylation		score0	HPRD	18691976
Y518	Phosphorylation		score0	HPRD	15592455, 19901323, 17389395, ...16497976
S724	Phosphorylation		score0	HPRD	18691976, 18669648
S728	Phosphorylation		score0	HPRD	18691976, 18669648
S730	Phosphorylation		score0	HPRD	18691976, 18669648
S785	Phosphorylation		score0	HPRD	18691976
Y827	Phosphorylation		score2	HPRD	18691976, 14739304, 18707149
Y859	Phosphorylation		score0	HPRD	19901323, 15951569, 17389395
Y860	Phosphorylation		score0	HPRD	15951569, 17389395
S881	Phosphorylation		score0	HPRD	18691976

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S39	Phosphorylation		score1	PhosphoSitePlus
	S806	Phosphorylation		score0	HPRD	18691976, 18669648

Q07912 (TNK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P10275 (AR)	Y269	score3	PhosphoSitePlus	17494760, 20623637, 20383201
P10275 (AR)	Y365	score2	PhosphoSitePlus	17494760
P31749 (AKT1)	Y176	score4	neXtProt RLIMS-P+	22322295, 20333297
P31749 (AKT1)	T308	score2	RLIMS-P+	25678401
P31749 (AKT1)	S473	score2	RLIMS-P+	25678401
P42768 (WAS)	S277	score2	neXtProt	16257963
P42768 (WAS)	Y291	score4	neXtProt PhosphoSitePlus	16257963, 16472662
P56945 (BCAR1)	Y165	score3	neXtProt	16247015, 17038317
P56945 (BCAR1)	Y249	score3	neXtProt	16247015, 17038317
P56945 (BCAR1)	Y410	score3	neXtProt	16247015, 17038317
Q07912 (TNK2)	Y284	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	14506255, 20623637, 16472662, ...20333297, 21169560, 20979614, 15308621
Q07912 (TNK2)	Y518	score2	neXtProt	21169560
Q07912 (TNK2)	Y827	score2	neXtProt	21169560
Q07912 (TNK2)	Y859	score2	neXtProt	21169560
Q07912 (TNK2)	Y872	score2	neXtProt	21169560
Q9NZC7 (WWOX)	Y287	score3	neXtProt PhosphoSitePlus	16288044
Q9Y4C1 (KDM3A)	Y1114	score2	PhosphoSitePlus	25148682
Q9Y5X1 (SNX9)	Y56	score2	neXtProt	11773052

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S77	C77	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
S81	N81	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S102	L102	Biomuta	DOID:5158 / pleural cancer [ cosmic ]
K124	N124	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S212	L212	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S445	F445	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T517	A517	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T603	N603	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S789	A789	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
T814	A814	Biomuta	DOID:363 / uterine cancer [ icgc ]
T829	N829	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
R839	L839	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y859	S859	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S881	G881	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S881	I881	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
T925	S925	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R933	Q933	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q07912 (TNK2)

Protein Information

Interactive Sequence View

Q07912 (TNK2) as Substrate

Q07912 (TNK2) as PTM Enzyme

PTM sites affected in variants