iPTMnet Report for Q07817 (BCL2L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07817 / B2CL1_HUMAN
Protein Name Bcl-2-like protein 1
Gene Name Name: BCL2L1
Synonyms:BCL2L,BCLX;
Organism Homo sapiens (Human)

PRO ID PR:Q07817
DAG View
PRO Name Bcl-2-like protein 1 (human)
Definition A Bcl-2-like protein 1 that is encoded in the genome of human.
Short Label hBCL2L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07817 (BCL2L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation RLIMS-P 24813943
K16 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T47 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 10617621, 17369848
T47 Phosphorylation P45983 (MAPK8) phospho.ELM   PhosphoSitePlus 10617621
T47 Phosphorylation P45984 (MAPK9) neXtProt   PhosphoSitePlus 10617621
S49 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28481930, 27398719, 21336504, ...28486788, 24621501, 21840391
S49 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   Signor 21840391, 21336504
S62 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 22617334, 24013390, 26022120, ...21683075, 17369848, 28038464, 24091677, 28481930, 24486574, 26188358, 27398719, 31942016, 24621501, 18974096, 28486788, 19917720, 23735052, 25156145, 23051936, 12633850
S62 Phosphorylation P45983 (MAPK8) phospho.ELM   PhosphoSitePlus   Signor 22617334, 12633850
S62 Phosphorylation P45984 (MAPK9) PhosphoSitePlus 22617334
S62 Phosphorylation P49137 (MAPKAPK2) neXtProt   PhosphoSitePlus 22617334
S62 Phosphorylation P49840 (GSK3A) PhosphoSitePlus 22617334
S62 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 22617334
S62 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P+ 22617334, 24621501
S62 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 22617334
S72 Phosphorylation RLIMS-P 27226901
S73 Phosphorylation RLIMS-P 27239332, 27226901
S74 Phosphorylation RLIMS-P 27226901
K87 Ubiquitination PhosphoSitePlus
T115 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 10617621
T115 Phosphorylation P45983 (MAPK8) phospho.ELM   PhosphoSitePlus 10617621
T115 Phosphorylation P45984 (MAPK9) neXtProt   PhosphoSitePlus 10617621
S145 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14457 (BECN1) T119 Q07817 (BCL2L1) increased_association eFIP 29717115
Phosphorylation Q99638 (RAD9A) S328 Q07817 (BCL2L1) unknown eFIP 23028682


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000026133 (mBAD/iso:1/Phos:2) NOT Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10949026
PR:000026140 (hBAD/iso:2/Phos:1) decreased Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10195903
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10949026
PR:000027471 (hBECN1/iso:1/Phos:1) decreased Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 19180116
PR:000044749 (hBAD/iso:2/UnMod) Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10195903
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q07812 (hBAX) PRO 8596636
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q61337 (mBAD) PRO 11583631
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:000028379 (hBID/iso:1/Clv:1) PRO 11583631
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:O54918 (mBCL2L11) PRO 11583631
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q92934-1 (hBAD/iso:1) PRO 10949026
PR:Q07817-1 (hBCL2L1/iso:1) NOT Interaction PR:000026133 (mBAD/iso:1/Phos:2) PRO 10949026
PR:Q07817-1 (hBCL2L1/iso:1) decreased Interaction PR:000026167 (mBAD/iso:1/Phos:1) PRO 10949026
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q16611 (hBAK1) PRO 8596636
PR:Q9BXH1-1 (hBBC3/iso:1) Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 11463391


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S72 I72 Biomuta DOID:363 / uterine cancer [ icgc ]