Protein Information

Cytoscape View

UniProt AC / UniProt ID Q07817 / B2CL1_HUMAN
Protein Name Bcl-2-like protein 1
Gene Name Name: BCL2L1
Organism Homo sapiens (Human)

PRO ID PR:Q07817
DAG View
PRO Name Bcl-2-like protein 1 (human)
Definition A Bcl-2-like protein 1 that is encoded in the genome of human.
Short Label hBCL2L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q07817 (BCL2L1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation RLIMS-P 24813943
K16 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T47 Phosphorylation P45983 (MAPK8) , P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 10617621, 17369848
S49 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28481930, 27398719, 21336504, ...28486788, 24621501, 21840391
S62 Phosphorylation Q16539 (MAPK14) , P45984 (MAPK9) , P49137 (MAPKAPK2) , P49840 (GSK3A) , P53350 (PLK1) , P49841 (GSK3B) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 22617334, 24013390, 23051936, ...21683075, 28481930, 28038464, 24091677, 26188358, 24486574, 26022120, 27398719, 24621501, 18974096, 28486788, 19917720, 23735052, 25156145, 17369848, 12633850
S72 Phosphorylation RLIMS-P 27226901
S73 Phosphorylation RLIMS-P 27239332, 27226901
S74 Phosphorylation RLIMS-P 27226901
K87 Ubiquitination PhosphoSitePlus
T115 Phosphorylation P45983 (MAPK8) , P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus 10617621

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14457 (BECN1) T119 Q07817 (BCL2L1) increased_association eFIP 29717115
Phosphorylation Q99638 (RAD9A) S328 Q07817 (BCL2L1) unknown eFIP 23028682

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000026133 (mBAD/iso:1/Phos:2) NOT Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10949026
PR:000026140 (hBAD/iso:2/Phos:1) decreased Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10195903
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10949026
PR:000027471 (hBECN1/iso:1/Phos:1) decreased Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 19180116
PR:000044749 (hBAD/iso:2/UnMod) Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10195903
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q92934-1 (hBAD/iso:1) PRO 10949026
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q61337 (mBAD) PRO 11583631
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:000028379 (hBID/iso:1/Clv:1) PRO 11583631
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:O54918 (mBCL2L11) PRO 11583631
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q16611 (hBAK1) PRO 8596636
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q07812 (hBAX) PRO 8596636
PR:Q07817-1 (hBCL2L1/iso:1) NOT Interaction PR:000026133 (mBAD/iso:1/Phos:2) PRO 10949026
PR:Q07817-1 (hBCL2L1/iso:1) decreased Interaction PR:000026167 (mBAD/iso:1/Phos:1) PRO 10949026
PR:Q9BXH1-1 (hBBC3/iso:1) Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 11463391

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S72 I72 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]