iPTMnet Report for Q07343 (PDE4B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07343 / PDE4B_HUMAN
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Gene Name Name: PDE4B
Synonyms:DPDE4;
Organism Homo sapiens (Human)

PRO ID PR:Q07343
DAG View
PRO Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B (human)
Definition A cAMP-specific 3',5'-cyclic phosphodiesterase 4B that is encoded in the genome of human.
Short Label hPDE4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07343 (PDE4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S133 Phosphorylation P17612 (PRKACA) phospho.ELM   PRO   PhosphoSitePlus 12441002, 12023945, 18220336
S138 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K251 Methylation PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
C492 Methylation IEDB 31844290
S520 Phosphorylation PhosphoSitePlus
K521 Acetylation PhosphoSitePlus
K536 Acetylation PhosphoSitePlus
K537 Acetylation PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
S659 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 11030732
Site PTM Type PTM Enzyme Score Source PMID
S133 Phosphorylation P17612 (PRKACA) HPRD 12441002
S140 Phosphorylation HPRD 19415658
S145 Phosphorylation HPRD 19415658
S732 Phosphorylation HPRD 15345747
Site PTM Type PTM Enzyme Score Source PMID
S487 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 11030732
Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S125 Phosphorylation HPRD 19415658
S130 Phosphorylation HPRD 19415658


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048720 (hPDE4B/Phos:1) pS133 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T41 A41 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S133 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S201 T201 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S732 C732 Biomuta DOID:4159 / skin cancer [ cosmic ]