iPTMnet Report for Q06413 (MEF2C)
Protein Information
| UniProt AC / UniProt ID | Q06413 / MEF2C_HUMAN |
| Protein Name | Myocyte-specific enhancer factor 2C |
| Gene Name | Name: MEF2C |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q06413 |
| PRO Name | myocyte-specific enhancer factor 2C (human) |
| Definition | A myocyte-specific enhancer factor 2C that is encoded in the genome of human. |
| Short Label | hMEF2C |
| Category | organism-gene |
DAG ViewQ06413 (MEF2C) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T20 | Phosphorylation | score2 | neXtProt | 15735306 | ||
| K23 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S59 | Phosphorylation | score3 | phospho.ELM RLIMS-P | 8663403 | ||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T80 | Phosphorylation | Q32MK0 (MYLK3) , Q9H1R3 (MYLK2) | score3 | IntAct PhosphoSitePlus Signor | 21556048 | |
| S82 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T87 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S98 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S110 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K116 | Acetylation | score3 | PhosphoSitePlus UniProt | 15831463 | ||
| K119 | Acetylation | score3 | PhosphoSitePlus UniProt | 15831463 | ||
| C134 | Methylation | score1 | IEDB | 31844290 | ||
| S150 | O-Glycosylation | score4 | GlyGen IEDB | 26280087, 28314751, 34925382 | ||
| S151 | O-Glycosylation | score2 | GlyGen IEDB | 26280087, 28314751 | ||
| S181 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S183 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 31848261, 27869121 | ||
| S192 | Phosphorylation | P51812 (RPS6KA3) | score3 | phospho.ELM RLIMS-P+ | 17630987 | |
| S222 | O-Glycosylation | score1 | GlyGen | 28314751, 28657654, 35254053 | ||
| S222 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 29431698, 23186163 | ||
| S228 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K234 | Acetylation | score3 | PhosphoSitePlus UniProt | 15831463 | ||
| K239 | Acetylation | score3 | PhosphoSitePlus UniProt | 15831463 | ||
| S240 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K252 | Acetylation | score3 | PhosphoSitePlus UniProt | 15831463 | ||
| K264 | Acetylation | score3 | PhosphoSitePlus UniProt | 15831463 | ||
| S271 | O-Glycosylation | score1 | GlyGen | 28314751, 28657654, 35254053 | ||
| T293 | Phosphorylation | Q16539 (MAPK14) | score4 | IEDB neXtProt phospho.ELM PRO RLIMS-P Signor UniProt | 9858528, 9384584, 32387766, ... | |
| T300 | Phosphorylation | Q16539 (MAPK14) | score4 | neXtProt phospho.ELM PRO Signor UniProt | 9384584, 9858528, 9069290 | |
| S387 | Phosphorylation | Q16539 (MAPK14) , Q13164 (MAPK7) | score4 | neXtProt phospho.ELM RLIMS-P Signor | 9384584, 17630987, 9858528, ... | |
| K391 | Sumoylation | score1 | PhosphoSitePlus | |||
| S396 | Phosphorylation | P06493 (CDK1) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt | 15340086, 16478538 | |
| S419 | Phosphorylation | score4 | PRO PhosphoSitePlus UniProt | 9384584, 9069290 | ||
| S445 | Phosphorylation | score2 | IEDB PhosphoSitePlus UniProt | 27920218, 23186163 | ||
| S453 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S459 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S461 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S59 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 8663403 | |
| S222 | Phosphorylation | score0 | HPRD | 19651622 | ||
| S240 | Phosphorylation | score0 | HPRD | 19651622 | ||
| T293 | Phosphorylation | Q16539 (MAPK14) | score1 | HPRD | 10805738 | |
| T300 | Phosphorylation | Q16539 (MAPK14) | score1 | HPRD | 9069290 | |
| S387 | Phosphorylation | Q13164 (MAPK7) , Q16539 (MAPK14) | score2 | HPRD | 9384584, 9069290 | |
| S396 | Phosphorylation | P06493 (CDK1) , P14635 (CCNB1) | score1 | HPRD | 16478538 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T293 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 9069290 | |
| T300 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 9069290 | |
| S387 | Phosphorylation | Q13164 (MAPK7) , Q16539 (MAPK14) | score3 | PhosphoSitePlus | 9384584, 9069290 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S98 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y105 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T108 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000048367 (hMEF2C/Phos:1) | pS396 | PRO | |||
| PR:000048368 (hMEF2C/Phos:2) | pT293,pT300,pS419 | PRO | 9069290 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S106 | F106 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| S110 | C110 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S110 | I110 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S110 | R110 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K119 | R119 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S183 | F183 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S192 | R192 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
| S222 | P222 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S387 | P387 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S419 | P419 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S445 | F445 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] | |
| S453 | L453 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S459 | N459 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
