Protein Information

Cytoscape View

UniProt AC / UniProt ID Q06413 / MEF2C_HUMAN
Protein Name Myocyte-specific enhancer factor 2C
Gene Name Name: MEF2C
Organism Homo sapiens (Human)

PRO ID PR:Q06413
DAG View
PRO Name myocyte-specific enhancer factor 2C (human)
Definition A myocyte-specific enhancer factor 2C that is encoded in the genome of human.
Short Label hMEF2C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q06413 (MEF2C) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T20 Phosphorylation neXtProt 15735306
K23 Ubiquitination PhosphoSitePlus
S59 Phosphorylation phospho.ELM   RLIMS-P 8663403
K64 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
T80 Phosphorylation IntAct   PhosphoSitePlus   Signor 21556048
T80 Phosphorylation Q32MK0 (MYLK3) Signor 21556048
T80 Phosphorylation Q9H1R3 (MYLK2) PhosphoSitePlus   Signor 21556048
S82 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus   UniProt 15831463
K119 Acetylation PhosphoSitePlus   UniProt 15831463
S181 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S192 Phosphorylation phospho.ELM   RLIMS-P+ 17630987
S192 Phosphorylation P51812 (RPS6KA3) RLIMS-P+ 17630987
S222 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29431698, 23186163
S228 Phosphorylation PhosphoSitePlus   UniProt 23186163
K234 Acetylation PhosphoSitePlus   UniProt 15831463
K239 Acetylation PhosphoSitePlus   UniProt 15831463
S240 Phosphorylation PhosphoSitePlus   UniProt 23186163
K252 Acetylation PhosphoSitePlus   UniProt 15831463
K264 Acetylation PhosphoSitePlus   UniProt 15831463
S271 O-Glycosylation GlyGen 28314751, 28657654
T293 Phosphorylation neXtProt   phospho.ELM   PRO   RLIMS-P   Signor   UniProt 9384584, 9858528, 9069290, ...10805738
T293 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   Signor 9858528, 9069290
T300 Phosphorylation neXtProt   phospho.ELM   PRO   Signor   UniProt 9384584, 9858528, 9069290
T300 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   Signor 9858528, 9069290
S387 Phosphorylation neXtProt   phospho.ELM   RLIMS-P   Signor 9384584, 17630987, 9858528, ...9069290
S387 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   Signor 9384584
S387 Phosphorylation Q16539 (MAPK14) neXtProt   Signor 9858528, 9069290
K391 Sumoylation PhosphoSitePlus
S396 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 15340086, 16478538
S396 Phosphorylation P06493 (CDK1) PhosphoSitePlus 16478538
S419 Phosphorylation PRO   PhosphoSitePlus   UniProt 9384584, 9069290
S445 Phosphorylation PhosphoSitePlus   UniProt 23186163
S453 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation HPRD 8663403
S59 Phosphorylation P68400 (CSNK2A1) HPRD 8663403
S222 Phosphorylation HPRD 19651622
S240 Phosphorylation HPRD 19651622
T293 Phosphorylation HPRD 10805738
T293 Phosphorylation Q16539 (MAPK14) HPRD 10805738
T300 Phosphorylation HPRD 9069290
T300 Phosphorylation Q16539 (MAPK14) HPRD 9069290
S387 Phosphorylation HPRD 9384584, 9069290
S387 Phosphorylation Q13164 (MAPK7) HPRD 9384584
S387 Phosphorylation Q16539 (MAPK14) HPRD 9069290
S396 Phosphorylation HPRD 16478538
S396 Phosphorylation P06493 (CDK1) HPRD 16478538
S396 Phosphorylation P14635 (CCNB1) HPRD 16478538
Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus 9069290
T293 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 9069290
T300 Phosphorylation PhosphoSitePlus 9069290
T300 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 9069290
S387 Phosphorylation PhosphoSitePlus 9384584, 9069290
S387 Phosphorylation Q13164 (MAPK7) PhosphoSitePlus 9384584
S387 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 9069290
Site PTM Type PTM Enzyme Score Source PMID
S98 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048367 (hMEF2C/Phos:1) pS396 PRO
PR:000048368 (hMEF2C/Phos:2) pT293,pT300,pS419 PRO 9069290

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q06413 (MEF2C) T80 Q9H1R3 (MYLK2) unknown eFIP 21556048

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T80 K80 Biomuta DOID:3571 / liver cancer [ icgc ]
S106 F106 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ]
S110 C110 Biomuta DOID:1324 / lung cancer [ cosmic ]
S110 I110 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K116 T116 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K119 R119 Biomuta DOID:1909 / melanoma [ cosmic ]
S183 F183 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S192 R192 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S222 P222 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S419 P419 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S459 N459 Biomuta DOID:363 / uterine cancer [ tcga ]