iPTMnet Report for Q05469 (LIPE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05469 / LIPS_HUMAN
Protein Name Hormone-sensitive lipase
Gene Name Name: LIPE
Organism Homo sapiens (Human)

PRO ID PR:Q05469
DAG View
PRO Name hormone-sensitive lipase (human)
Definition A hormone-sensitive lipase that is encoded in the genome of human.
Short Label hLIPE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05469 (LIPE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T188 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S552 Phosphorylation RLIMS-P 22166756, 21338323, 22493722
S565 Phosphorylation RLIMS-P 18398140, 23940618, 19755426, ...15308678, 33502468, 22982310, 21042876, 33758172, 19996383
K624 Ubiquitination PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
S660 Phosphorylation RLIMS-P 25790476, 23907381, 19755426, ...21186937, 21498783, 16690773, 16188906, 23576171, 29500454, 28123934, 31427606
Y741 Phosphorylation PhosphoSitePlus
T813 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
S853 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 3345839, 16188906, 2537200, ...9417067
S853 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 2537200, 16188906, 3345839
S853 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus 2537200
S855 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15033481, 9636039, 2537200, ...15308678, 19018281, 16188906
S855 Phosphorylation P17612 (PRKACA) neXtProt   Signor 19018281, 9636039
S855 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 9636039, 2537200, 16188906
S855 Phosphorylation Q14012 (CAMK1) PhosphoSitePlus 2537200
S855 Phosphorylation Q9UQM7 (CAMK2A) Signor 9636039
K872 Ubiquitination PhosphoSitePlus
S950 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus 19018281, 9417067
S950 Phosphorylation P17612 (PRKACA) neXtProt 19018281
S951 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus 16188906, 9417067
S951 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 16188906
T955 Phosphorylation PhosphoSitePlus
T1015 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T188 Phosphorylation HPRD 20230923
T189 Phosphorylation HPRD 20230923
S565 Phosphorylation HPRD 16188906
S853 Phosphorylation HPRD 9417067
S853 Phosphorylation P17612 (PRKACA) HPRD 9417067
S855 Phosphorylation HPRD 9417067
S855 Phosphorylation P17612 (PRKACA) HPRD 9417067
T891 Phosphorylation HPRD 11581251
T891 Phosphorylation P27361 (MAPK3) HPRD 11581251
T891 Phosphorylation P28482 (MAPK1) HPRD 11581251
S950 Phosphorylation HPRD 14641008, 9417067
S950 Phosphorylation P17612 (PRKACA) HPRD 14641008, 9417067
S951 Phosphorylation HPRD 14641008, 9417067
S951 Phosphorylation P17612 (PRKACA) HPRD 14641008, 9417067
Site PTM Type PTM Enzyme Score Source PMID
S552 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048216 (hLIPE/Phos:1) pS950,pS951 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T188 A188 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T189 M189 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K872 N872 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T891 I891 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1015 M1015 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]