Protein Information

Cytoscape View

UniProt AC / UniProt ID Q05469 / LIPS_HUMAN
Protein Name Hormone-sensitive lipase
Gene Name Name: LIPE
Organism Homo sapiens (Human)

PRO ID PR:Q05469
DAG View
PRO Name hormone-sensitive lipase (human)
Definition A hormone-sensitive lipase that is encoded in the genome of human.
Short Label hLIPE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q05469 (LIPE) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T188 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S552 Phosphorylation RLIMS-P 22166756, 21338323, 22493722
S565 Phosphorylation RLIMS-P 18398140, 23940618, 19755426, ...22982310, 16188906, 19996383
K624 Ubiquitination PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PRO
S650 Phosphorylation PRO
S660 Phosphorylation RLIMS-P 23907381, 16690773, 16188906, ...21498783, 19755426
Y741 Phosphorylation PhosphoSitePlus
T813 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
S853 Phosphorylation P17612 (PRKACA) , Q13976 (PRKG1) neXtProt   phospho.ELM   PhosphoSitePlus 2537200, 16188906, 3345839, ...9417067
S855 Phosphorylation Q14012 (CAMK1) , P17612 (PRKACA) , Q13131 (PRKAA1) , Q9UQM7 (CAMK2A) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15033481, 9636039, 2537200, ...15308678, 19018281, 16188906
K872 Ubiquitination PhosphoSitePlus
S950 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus 19018281, 9417067
S951 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus 16188906, 9417067
T955 Phosphorylation PhosphoSitePlus
T1015 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T188 Phosphorylation HPRD 20230923
T189 Phosphorylation HPRD 20230923
S565 Phosphorylation HPRD 16188906
S853 Phosphorylation P17612 (PRKACA) HPRD 9417067
S855 Phosphorylation P17612 (PRKACA) HPRD 9417067
T891 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 11581251
S950 Phosphorylation P17612 (PRKACA) HPRD 14641008, 9417067
S951 Phosphorylation P17612 (PRKACA) HPRD 14641008, 9417067
Site PTM Type PTM Enzyme Score Source PMID
S552 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048216 (hLIPE/Phos:1) pS649,pS650 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T188 A188 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1324 / lung cancer [ cosmic, tcga ]
T189 M189 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K872 N872 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T891 I891 Biomuta DOID:1909 / melanoma [ cosmic ]
T1015 M1015 Biomuta DOID:10534 / stomach cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]