iPTMnet Report Q04724 TLE1

Protein Information

UniProt AC / UniProt ID	Q04724 / TLE1_HUMAN
Protein Name	Transducin-like enhancer protein 1
Gene Name	Name: TLE1
Organism	Homo sapiens (Human)

PRO ID	PR:Q04724 DAG View
PRO Name	transducin-like enhancer protein 1 (human)
Definition	A transducin-like enhancer protein 1 that is encoded in the genome of human.
Short Label	hTLE1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q04724 (TLE1) as Substrate

Q04724

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position R6 K30 K54 S235 S239 S244 S253 S259 S263 S267 K281 S284 S285 S286 S289 T290 S292 S293 S305 T312 S318 T319 R338 K343 R359 K504 R641 Y692 S699 C700 S703 K718 K761 K762	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all GlyGen HPRD IEDB PRO PhosphoSitePlus Signor UniProt phospho.ELM	PMID
	Ubiquitination		score1	PRO
R6	Methylation		score1	PhosphoSitePlus
K30	Ubiquitination		score1	PhosphoSitePlus
K54	Ubiquitination		score1	PhosphoSitePlus
S235	Phosphorylation		score1	PhosphoSitePlus
S239	Phosphorylation	P68400 (CSNK2A1)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	21406692, 22354967, 15367661
S244	Phosphorylation		score1	PhosphoSitePlus
S253	Phosphorylation	P68400 (CSNK2A1)	score3	PhosphoSitePlus Signor	22354967
S259	Phosphorylation		score1	PhosphoSitePlus
S263	Phosphorylation		score1	PhosphoSitePlus
S267	Phosphorylation		score1	PhosphoSitePlus
K281	Acetylation		score1	PhosphoSitePlus
S284	Phosphorylation		score1	PhosphoSitePlus
S285	Phosphorylation		score2	HPRD PhosphoSitePlus	19664995
S286	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	19413330, 21406692, 19664994, ...19664995
S289	O-Glycosylation		score1	GlyGen	30620550
S289	Phosphorylation		score1	PhosphoSitePlus
T290	O-Glycosylation		score1	GlyGen	30620550
T290	Phosphorylation		score1	PhosphoSitePlus
S292	Phosphorylation		score1	PhosphoSitePlus
S293	O-Glycosylation		score1	GlyGen	30620550
S305	Phosphorylation		score1	PhosphoSitePlus
T312	Phosphorylation		score1	PhosphoSitePlus
S318	Phosphorylation		score1	IEDB	32387766
T319	Phosphorylation		score1	PhosphoSitePlus
R338	Methylation		score1	PhosphoSitePlus
K343	Methylation		score1	PhosphoSitePlus
R359	Methylation		score1	PhosphoSitePlus
K504	Ubiquitination		score1	PhosphoSitePlus
R641	Methylation		score1	PhosphoSitePlus
Y692	Phosphorylation		score1	PhosphoSitePlus
S699	Phosphorylation		score1	PhosphoSitePlus
C700	Methylation		score1	IEDB	31844290
S703	Phosphorylation		score1	PhosphoSitePlus
K718	Acetylation		score1	PhosphoSitePlus
K718	Ubiquitination		score1	PhosphoSitePlus
K761	Ubiquitination		score1	PhosphoSitePlus
K762	Sumoylation		score1	PhosphoSitePlus

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000049463 (hTLE1/UbiqLys+)	Sites Select all ub	PTM Enzyme	Source Select all PRO	PMID
	PR:000049463 (hTLE1/UbiqLys+)	ub		PRO

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position R6 S285 T290 S305 T312 R338 R641 S703	Variant Select all C338 F703 K641 M290 M312 Q6 R305 T285	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R6	Q6	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S285	T285	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T290	M290	Biomuta	DOID:363 / uterine cancer [ icgc ]
S305	R305	Biomuta	DOID:1319 / brain cancer [ cosmic ]
T312	M312	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R338	C338	Biomuta	[ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R641	K641	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
S703	F703	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q04724 (TLE1)

Protein Information

Interactive Sequence View

Q04724 (TLE1) as Substrate

Proteoforms

PTM sites affected in variants