iPTMnet Report for Q04724 (TLE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04724 / TLE1_HUMAN
Protein Name Transducin-like enhancer protein 1
Gene Name Name: TLE1
Organism Homo sapiens (Human)

PRO ID PR:Q04724
DAG View
PRO Name transducin-like enhancer protein 1 (human)
Definition A transducin-like enhancer protein 1 that is encoded in the genome of human.
Short Label hTLE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04724 (TLE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
R6 Methylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S239 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 22354967, 15367661
S239 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 22354967, 15367661
S244 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus   Signor 22354967
S253 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 22354967
S259 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K281 Acetylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S285 Phosphorylation HPRD   PhosphoSitePlus 19664995
S286 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 19664994, ...19664995
S289 O-Glycosylation GlyGen 30620550
S289 Phosphorylation PhosphoSitePlus
T290 O-Glycosylation GlyGen 30620550
T290 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
S293 O-Glycosylation GlyGen 30620550
S305 Phosphorylation PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
S318 Phosphorylation IEDB 32387766
T319 Phosphorylation PhosphoSitePlus
R338 Methylation PhosphoSitePlus
K343 Methylation PhosphoSitePlus
R359 Methylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
R641 Methylation PhosphoSitePlus
Y692 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
C700 Methylation IEDB 31844290
S703 Phosphorylation PhosphoSitePlus
K718 Acetylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
K762 Sumoylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049463 (hTLE1/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R6 Q6 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S285 T285 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T290 M290 Biomuta DOID:363 / uterine cancer [ icgc ]
S305 R305 Biomuta DOID:1319 / brain cancer [ cosmic ]
T312 M312 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R338 C338 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R641 K641 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S703 F703 Biomuta DOID:4159 / skin cancer [ cosmic ]